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首页> 外文期刊>Genes to cells : >Absence of primary cilia in cell cycle-arrested human breast cancer cells
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Absence of primary cilia in cell cycle-arrested human breast cancer cells

机译：细胞周期停滞的人乳腺癌细胞中不存在原发纤毛

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Previous studies using cultured cells showed that primary cilia are present in quiescent cells, but are absent in proliferating cells. We studied here the relationship between the presence or absence of primary cilia and the cell cycle arrest of normal epithelial cells and cancer cells in the human normal breast and breast cancer tissues. In normal breast tissues, although most epithelial cells were nonproliferating as estimated by the immunofluorescence staining of the proliferation marker Ki-67, primary cilia were present only in 20—40% of the epithelial cells. In breast cancer tissues, primary cilia were not observed in any of the breast cancer cells. Furthermore, primary cilia were hardly observed in the nonproliferating cancer cells in the orthotopic and metastatic human breast cancer xenograft tumors in mice. These results indicate that the absence of primary cilia does not necessarily represent the proliferating phases of normal epithelial cells and cancer cells.
机译：以前使用培养的细胞进行的研究表明，原纤毛存在于静止细胞中，但在增殖细胞中却不存在。我们在这里研究了人类正常乳腺癌和乳腺癌组织中原发纤毛的存在与否与正常上皮细胞和癌细胞的细胞周期停滞之间的关系。在正常乳腺组织中，尽管通过增殖标记Ki-67的免疫荧光染色估计大多数上皮细胞均不增殖，但原纤毛仅存在于20-40％的上皮细胞中。在乳腺癌组织中，任何乳腺癌细胞均未观察到原发纤毛。此外，在小鼠原位和转移性人乳腺癌异种移植肿瘤的非增殖癌细胞中几乎未观察到原发纤毛。这些结果表明，原发纤毛的缺乏不一定代表正常上皮细胞和癌细胞的增殖期。

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