• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genes to cells : >Hst3 and Hst4 histone deacetylases regulate replicative lifespan by preventing genome instability in Saccharomyces cerevisiae
【24h】

Hst3 and Hst4 histone deacetylases regulate replicative lifespan by preventing genome instability in Saccharomyces cerevisiae

机译：Hst3和Hst4组蛋白脱乙酰基酶通过防止啤酒酵母中的基因组不稳定来调节复制寿命

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The acetylation of histone H3 on lysine 56 (H3-K56) occurs during S phase and contributes to the processes of DNA damage repair and histone gene transcription. Hst3 and Hst4 have been implicated in the removal of histone H3-K56 acetylation in Saccharomyces cerevisiae. Here, we show that Hst3 and Hst4 regulate the replicative lifespan of S. cerevisiae mother cells. An hst3 Delta hst4 Delta double-mutant strain, in which acetylation of histone H3-K56 persists throughout the genome during the cell cycle, exhibits genomic instability, which is manifested by a loss of heterozygosity with cell aging. Furthermore, we show that in the absence of other proteins Hst3 and Hst4 can deacetylate nucleosomal histone H3-K56 in a nicotinamide adenine dinucleotide(NAD)+-dependent manner. Our results suggest that Hst3 and Hst4 regulate replicative lifespan through their ability to deacetylate histone H3-K56 to minimize genomic instability.
机译：组蛋白H3在赖氨酸56（H3-K56）上的乙酰化发生在S期，并有助于DNA损伤修复和组蛋白基因转录的过程。 Hst3和Hst4与酿酒酵母中组蛋白H3-K56乙酰化的去除有关。在这里，我们显示Hst3和Hst4调节酿酒酵母母细胞的复制寿命。 hst3 Delta hst4 Delta双突变株，其中组蛋白H3-K56的乙酰化在整个细胞周期中持续存在于整个基因组中，表现出基因组不稳定，表现为随着细胞衰老杂合性的丧失。此外，我们显示，在没有其他蛋白质的情况下，Hst3和Hst4可以以烟酰胺腺嘌呤二核苷酸（NAD）+依赖性方式使核小体组蛋白H3-K56脱乙酰化。我们的结果表明，Hst3和Hst4通过将组蛋白H3-K56脱乙酰化的能力来调节复制寿命，以最大程度地降低基因组不稳定性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号