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首页> 外文期刊>Genomics >Genomewide comparative phylogenetic and molecular evolutionary analysis of tubby-like protein family in Arabidopsis, rice, and poplar.
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Genomewide comparative phylogenetic and molecular evolutionary analysis of tubby-like protein family in Arabidopsis, rice, and poplar.

机译：全基因组比较系统发育和分子进化分析，拟南芥，水稻和杨树的tubby样蛋白家族。

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摘要

Tubby-like proteins, which are characterized by a highly conserved tubby domain, play an important role in the maintenance and function of neuronal cells during postdifferentiation and development in mammals. In additional to the tubby domain, most tubby-like proteins in plants also possess an F-box domain. Plants also appear to harbor a large number of TLP genes. To gain insight into how TLP genes evolved in plants, we conducted a comparative phylogenetic and molecular evolutionary analysis of the tubby-like protein gene family in Arabidopsis, rice, and poplar. Genomewide screening identified 11 TLP genes in Arabidopsis, 14 in rice, and 11 in poplar. Phylogenetic trees, domain organizations, and intron/exon structures classified this family into three subfamilies and indicated that species-specific expansion contributed to the evolution of this family in plants. We determined that in rice and poplar, the tubby-like protein family had expanded mainly through segmental duplication events. Tissue-specific expression analysis indicated that functional diversification of the duplicated TLP genes was a major feature of long-term evolution. Our results also demonstrated that the tubby and F-box domains had co-evolved during the evolution of proteins containing both domains.
机译：具有高度保守的tubby结构域特征的Tubby样蛋白在哺乳动物的后分化和发育过程中在神经元细胞的维持和功能中起重要作用。除tubby域外，植物中的大多数tubby样蛋白还具有一个F-box域。植物也似乎具有大量的TLP基因。为了深入了解TLP基因如何在植物中进化，我们对拟南芥，水稻和杨树中的tubby-like蛋白基因家族进行了比较的系统发育和分子进化分析。全基因组筛选确定了拟南芥中的11个TLP基因，水稻中的14个和杨树中的11个。系统发育树，结构域组织和内含子/外显子结构将该科分为三个亚科，表明物种特异性的扩增促进了该科在植物中的进化。我们确定在水稻和杨树中，tubby-like蛋白家族主要通过节段性复制事件扩展。组织特异性表达分析表明，重复的TLP基因的功能多样化是长期进化的主要特征。我们的研究结果还表明，在包含两个结构域的蛋白质进化过程中，tubby和F-box结构域共同进化。

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