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首页> 外文期刊>Growth hormone and IGF research: Official journal of the Growth Hormone Research Society and the International IGF Research Society >Changes in total ghrelin within the somatotropic axis in severe burn patients: comparison of those with inhalation injury and those without inhalation injury.
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Changes in total ghrelin within the somatotropic axis in severe burn patients: comparison of those with inhalation injury and those without inhalation injury.

机译：重度烧伤患者生长激素轴内总生长激素释放肽的变化：吸入性损伤与未吸入性损伤的比较。

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OBJECTIVE: The aims of this study were to clarify changes in total ghrelin within the somatotropic axis in severe burn subjects with or without inhalation injury as well as the responsiveness of GH, IGF-1, and IGFBP-3 to the different severity of burn injuries. DESIGN: Twenty-three patients with severe burn injuries (30% of 2nd degree burns or 10% of 3rd degree burns) were classified into 2 groups according to inhalation injury: group I with inhalation injury (n=9) and group II without inhalation injury (n=14). The evaluations of serum GH, IGF-1, IGFBP-3, and total ghrelin were done on post-burn injury days 3, 7, 14, 21, and 40. Cortisol levels were measured from 24-h urine collections on post-burn injury days 7 and 21. RESULTS: In all subjects, the levels of GH fluctuated throughout the observation period whereas IGF-1 showed an initial decline with nadir on day 7 and a subsequent increase through day 40. The levels of IGFBP-3 and total ghrelin showed a progressive increase with nadir on day 3. Compared with the group II, the GH levels were increased in the group I on post-burn days 3, 7, and 14, of which day 7 showed statistical significance (p0.05). The levels of IGF-1 (days 7 and 21; p0.05) and IGFBP-3 (days 7, 14, 21, and 40; p0.05, p0.01, p0.05, p0.05, respectively) were lower in the group I than in the group II throughout the study period. On post-burn injury days 3, 7, 14, and 21, total ghrelin levels were lower in the group I than in the group II with statistical significance on post-burn day 7 (p0.001). CONCLUSIONS: Our present data show a concurrence of elevated GH levels and decreased IGF-I, IGFBP-3, and total ghrelin levels during the early burn injury period, in addition to more GH burst amplitude as well as greater falling of IGF-I, IGFBP-3 and total ghrelin levels proportional to the severity of burn injury. Further studies are needed to ascertain whether acyl- and desacyl-ghrelin instead of total ghrelin are completely independent of increased GH or other stress mediators, and whether GH-releasing hormone (GHRH) mainly stimulates the production and release of GH in acute critical conditions.
机译：目的：本研究旨在阐明有或没有吸入损伤的严重烧伤患者生长激素轴内总生长激素释放肽的变化，以及GH，IGF-1和IGFBP-3对不同烧伤严重程度的反应性。设计：将23例严重烧伤（> 2级烧伤> 30％或> 3级烧伤> 10％）的患者按吸入伤分为两组：第一组为吸入伤（n = 9），第二组没有吸入伤害（n = 14）。在烧伤后第3、7、14、21和40天对血清GH，IGF-1，IGFBP-3和总生长素释放肽进行评估。在烧伤后24小时尿液中测量皮质醇水平结果：在第7天和第21天受伤。结果：在所有受试者中，GH的水平在整个观察期内波动，而IGF-1在第7天出现最低点的最初下降，然后在第40天上升。IGFBP-3和总水平ghrelin在第3天出现最低点，并逐渐增加。与II组相比，I组在烧伤后第3、7和14天的GH水平升高，其中第7天具有统计学意义（p <0.05） 。 IGF-1（第7和21天; p <0.05）和IGFBP-3（第7、14、21和40天; p <0.05，p <0.01，p <0.05，p <0.05）的水平分别为在整个研究期间，第一组的患病率低于第二组的患病率。在烧伤后第3、7、14和21天，I组的总生长素释放肽水平低于II组，在烧伤后第7天具有统计学意义（p <0.001）。结论：我们目前的数据显示，在烧伤早期，GH升高，IGF-I，IGFBP-3和总生长素释放肽水平降低同时出现，此外还有更多的GH爆发幅度以及IGF-I下降更大， IGFBP-3和总生长素释放肽水平与烧伤严重程度成正比。需要进一步研究以确定酰基和脱酰基生长素释放肽，而不是总生长素释放肽是否完全独立于生长激素升高或其他应激介质，以及生长激素释放激素（GHRH）是否在急性危急情况下主要刺激生长激素的产生和释放。

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