...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society >A comparison of gonadotropin-releasing hormone (GnRH) antagonist and GnRH agonist flare protocols for poor responders undergoing in vitro fertilization.
【24h】

A comparison of gonadotropin-releasing hormone (GnRH) antagonist and GnRH agonist flare protocols for poor responders undergoing in vitro fertilization.

机译：促性腺激素释放激素（GnRH）拮抗剂和GnRH激动剂耀斑方案对接受体外受精的不良反应者的比较。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To compare stimulation profiles, pregnancy, and live birth rates in poor responders during in vitro fertilization (IVF) cycles using either a gonadotropin-releasing hormone (GnRH) antagonist (cetrorelix) or a GnRH agonist flare protocol (leuprolide). DESIGN: Retrospective chart review. SETTING: A university-affiliated IVF program. PATIENT(S): Women designated as poor responders based on a prior stimulation cycle or baseline follicle-stimulating hormone (FSH) level of >10 mIU/mL, who needed at least 375 IU of starting daily gonadotropins in the study cycle. INTERVENTION(S): Administration of GnRH agonist flare or GnRH antagonist protocol. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate, live birth rate. RESULT(S): For 68 GnRH antagonist and 45 GnRH agonist flare cycles, the groups were similar with respect to age (38.8 versus 38.6 years) and basal FSH concentration (8.33 versus 8.65 mIU/mL). No statistically significant differences between the protocol types were noted in peak estradiol levels, amount of gonadotropins used, number of oocytes obtained, or embryos transferred. The pregnancy rates (40% versus 45.2%) and live birth rates (27.7% versus 31.7%) in the GnRH antagonist and flare groups, respectively, were similar. CONCLUSION(S): We achieved excellent and comparable pregnancy and live birth rates in poor responders of advanced reproductive age with the use of either GnRH antagonist or flare protocol.
机译：目的：比较使用促性腺激素释放激素（GnRH）拮抗剂（cetrorelix）或GnRH激动剂耀斑方案（leuprolide）在体外受精（IVF）周期中反应较差的人的刺激概况，妊娠和活产率。设计：回顾性图表审查。地点：大学附属的试管婴儿计划。患者：根据先前的刺激周期或基线卵泡刺激素（FSH）水平> 10 mIU / mL被指定为反应不良的女性，她们在研究周期中需要至少375 IU的每日起始促性腺激素。干预措施：给予GnRH激动剂耀斑或GnRH拮抗剂方案。主要观察指标：临床妊娠率，活产率。结果：对于68 GnRH拮抗剂和45 GnRH激动剂耀斑周期，各组的年龄（38.8对38.6岁）和基础FSH浓度（8.33对8.65 mIU / mL）相似。在峰值雌二醇水平，所用促性腺激素的量，获得的卵母细胞数或转移的胚胎中，没有发现协议类型之间的统计学差异。 GnRH拮抗剂组和耀斑组的妊娠率（40％比45.2％）和活产率（27.7％比31.7％）相似。结论：通过使用GnRH拮抗剂或耀斑方案，我们在晚期生殖反应较差的应答者中获得了极好的可比妊娠和活产率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号