• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research >In vitro and in vivo safety assessment of edible blue-green algae, Nostoc commune var. sphaeroides Kutzing and Spirulina plantensis.
【24h】

In vitro and in vivo safety assessment of edible blue-green algae, Nostoc commune var. sphaeroides Kutzing and Spirulina plantensis.

机译：食用蓝绿藻Nostoc comvune var的体外和体内安全性评估。 sphaeroides Kutzing和螺旋藻plantensis。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Blue-green algae (BGA) have been consumed as food and herbal medicine for centuries. However, safety for their consumption has not been well investigated. This study was undertaken to evaluate in vitro and in vivo toxicity of cultivated Nostoc commune var. sphaeroides Kutzing (NO) and Spirulina platensis (SP). Neither NO nor SP contained detectable levels of microcystin (MC)-LA, MC-RR, MC-LW and MC-LR by LC/MS/MS. Cell viability remained approximately 70-80% when HepG2 cells were incubated with 0-500 mug/ml of hexane, chloroform, methanol and water-extractable fractions of NO and SP. Four-week-old male and female C57BL/6J mice were fed an AIN-93G/M diet supplemented with 0%, 2.5% or 5% of NO and SP (wt/wt) for 6 months. For both genders, BGA-rich diets did not induce noticeable abnormality in weight gain and plasma alanine aminotransferase (ALT) and aspartate aminotransferase concentrations except a significant increase in plasma ALT levels by 2.5% NO supplementation in male mice at 6 month. Histopathological analysis of livers, however, indicated that BGA did not cause significant liver damage compared with controls. In conclusion, our results suggest that NO and SP are free of MC and the long-term dietary supplementation of up to 5% of the BGA may be consumed without evident toxic side-effects.
机译：蓝藻（BGA）被用作食品和草药已有数百年历史了。但是，尚未对其食用安全性进行充分研究。进行这项研究以评估栽培的Nostoc公社变种的体外和体内毒性。球菌Kutzing（NO）和Spirulina platensis（SP）。通过LC / MS / MS，NO和SP均未检测到可检测水平的微囊藻毒素（MC）-LA，MC-RR，MC-LW和MC-LR。当将HepG2细胞与0-500杯/毫升的己烷，氯仿，甲醇以及水和可萃取的NO和SP馏分一起孵育时，细胞活力保持约70-80％。给四周大的雄性和雌性C57BL / 6J小鼠喂以AIN-93G / M日粮，其中补充了0％，2.5％或5％的NO和SP（wt / wt），为期6个月。对于这两种性别，富含BGA的饮食都不会引起体重增加和血浆丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶浓度的明显异常，除了在6个月时雄性小鼠血浆ALT水平显着增加了2.5％NO补充外。但是，肝脏的组织病理学分析表明，与对照组相比，BGA并未引起明显的肝损伤。总之，我们的结果表明，NO和SP不含MC，长期饮食补充最多达5％的BGA可能没有明显的毒副作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号