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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effects of aluminum oxide (Al2O3) nanoparticles on ECG, myocardial inflammatory cytokines, redox state, and connexin 43 and lipid profile in rats: possible cardioprotective effect of gallic acid
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Effects of aluminum oxide (Al2O3) nanoparticles on ECG, myocardial inflammatory cytokines, redox state, and connexin 43 and lipid profile in rats: possible cardioprotective effect of gallic acid

机译：氧化铝（Al2O3）纳米粒对大鼠心电图，心肌炎性细胞因子，氧化还原状态和连接蛋白43和脂质分布的影响：没食子酸可能的心脏保护作用

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摘要

The objectives of present study were to examine the effects of aluminum oxide (Al2O3) nanoparticles on myocardial functions, electrical activities, morphology, inflammation, redox state, and myocardial expression of connexin 43 (Cx43) and the effect of gallic acid (GA) on these effects in a rat animal model. Forty male albino rats were divided into 4 equal groups: the control (normal) group; the Al2O3 group, rats received Al2O3 (30 mg.kg(-1), i.p.) daily for 14 days; the nano-alumina group, rats received nano-alumina (30 mg.kg(-1), i.p.) daily for 14 days; and the nano-alumina + GA group, rats received GA (100 mg.kg(-1) orally once daily) for 14 days before nano-alumina administration. The results showed disturbed ECG variables and significant increases in serum levels of LDH, creatine phosphokinase (CPK), CK-MB, triglycerides (TGs), cholesterol and LDL, nitric oxide (NO), and TNF-alpha and myocardial concentrations of NO, TNF-alpha, and malondialdehyde (MDA), with significant decreases in serum HDL and myocardial GSH, SOD, catalase (CAT), and Cx43 expression in the nano-alumina group. Pretreatment with GA improved significantly all parameters except serum and myocardial NO. We concluded that chronic administration of Al2O3 NPs caused myocardial dysfunctions, and pretreatment with GA ameliorates myocardial injury induced by nano-alumina, probably through its hypolipidaemic, anti-inflammatory, and antioxidant effects and upregulation of Cx43 in heart.
机译：本研究的目的是检查氧化铝（Al2O3）纳米颗粒对心肌功能，电活动，形态，炎症，氧化还原状态和连接蛋白43（Cx43）心肌表达的影响，以及没食子酸（GA）对心肌的影响。这些作用在大鼠动物模型中。将40只雄性白化病大鼠分为4组，分别为对照组（正常组）和对照组。 Al2O3组，大鼠每天接受Al2O3（30 mg.kg（-1），腹腔注射），持续14天;纳米氧化铝组的大鼠每天接受纳米氧化铝（30 mg.kg（-1），腹腔注射），共14天;以及纳米氧化铝+ GA组，大鼠接受GA（每天一次口服100 mg.kg（-1））持续14天。结果显示，心电图变量受干扰，血清中的LDH，肌酸磷酸激酶（CPK），CK-MB，甘油三酸酯（TGs），胆固醇和LDL，一氧化氮（NO）以及TNF-α和心肌中的NO浓度显着增加， TNF-α和丙二醛（MDA），在纳米氧化铝组中血清HDL和心肌GSH，SOD，过氧化氢酶（CAT）和Cx43表达显着降低。用GA预处理可显着改善除血清和心肌NO以外的所有参数。我们得出的结论是，长期施用Al2O3 NP会导致心肌功能障碍，而GA预处理可以缓解纳米氧化铝引起的心肌损伤，这可能是由于其降血脂，抗炎和抗氧化作用以及心脏中Cx43的上调。

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