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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Comparative effects of piperine and simvastatin in fat accumulation and antioxidative status in high fat-induced hyperlipidemic rats
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Comparative effects of piperine and simvastatin in fat accumulation and antioxidative status in high fat-induced hyperlipidemic rats

机译：胡椒碱和辛伐他汀对高脂诱导的高脂血症大鼠脂肪积累和抗氧化状态的比较作用

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摘要

The present study investigated the comparative effects of piperine (PIP) - the active ingredient of black and long peppers - and simvastatin (SIM) on hepatic steatosis in hyperlipidemic rats. Male Wistar rats were fed a cholesterol mixture daily by intragastric gavage for 8 weeks. Piperine was given by oral gavage 8 h after cholesterol feeding. The animals were divided into 4 groups: control, high fat (HF), high fat plus 40 mg PIP/kg, and high fat plus 2mg SIM/kg. At the end of the treatment, liver cholesterol, triglyceride, thiobaribituric reacting substances, superoxide dismutase (SOD), serum aminotransferase (AST), and alanine transferase (ALT) were measured. The result demonstrated that PIP and SIM significantly reduced the accumulation of cholesterol, triglyceride, and lipid peroxidation in the liver, while elevation of SOD was observed. The activities of AST and ALT significantly decreased in PIP when compared with the HF group. Our in vitro study of pancreatic lipase also showed the inhibitory effect of PIP higher than 30% at 5 mmol/L. These results demonstrate that PIP has beneficial effects in the treatment and (or) prevention of fat accumulation in the liver and that this mechanism is due to the inhibition of pancreatic lipase and the improvement of oxidative status.
机译：本研究调查了胡椒和黑胡椒的活性成分胡椒碱（PIP）和辛伐他汀（SIM）对高脂血症大鼠肝脂肪变性的比较作用。每天通过灌胃法给雄性Wistar大鼠喂食胆固醇混合物，持续8周。胆固醇喂养后8小时通过口服管饲法给予胡椒碱。将动物分为4组：对照组，高脂（HF），高脂加40 mg PIP / kg和高脂加2m​​g SIM / kg。在治疗结束时，测量肝胆固醇，甘油三酸酯，硫代巴比妥反应物，超氧化物歧化酶（SOD），血清氨基转移酶（AST）和丙氨酸转移酶（ALT）。结果表明，PIP和SIM显着降低了肝脏中胆固醇，甘油三酸酯和脂质过氧化的积累，同时观察到SOD升高。与HF组相比，PIP的AST和ALT活性明显降低。我们对胰腺脂肪酶的体外研究还显示，在5 mmol / L时，PIP的抑制作用高于30％。这些结果表明，PIP在治疗和/或预防肝脏中的脂肪积聚方面具有有益的作用，并且该机理是由于抑制了胰腺脂肪酶和改善了氧化状态。

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