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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effect of vitamin A deficiency on cardiovascular function in the rat.
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Effect of vitamin A deficiency on cardiovascular function in the rat.

机译：维生素A缺乏症对大鼠心血管功能的影响。

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摘要

Selected parameters of cardiovascular function were evaluated in vitamin A-deficient rats at 70 days of age. Resting heart rate was increased by an average of 100 bpm (21.4+/-2.7%), whereas resting systolic blood pressure was normal in vitamin A-deficient animals. The maximal contractile force developed per milligram weight of tissue by aortic rings excised from vitamin A-deficient animals was reduced in response to high potassium (-25.0+/-8.7%) and phorbol 12,13-dibutyrate (-36.8+/-8.4%) but was only slightly reduced in response to norepinephrine (-17.8+/-11.1%). Intimal rubbing to remove the endothelium had no effect on the loss in contractile responsiveness, and the relaxant response to acetylcholine was similar between control and vitamin A-deficient tissue groups. This suggests that the decrease in contractility of vascular smooth muscle from the vitamin A-deficient rats did not involve altered release of endothelium-derived vasoactive factors. Western blot analysis suggested a reduction in the protein levels of several differentiation markers including alpha-actin (-22%), calponin (-37%), desmin (-37%), and vinculin (-40%), whereas the level of PKCalpha was unchanged from control values. Our findings indicate a significant decrease in contractile responsiveness of aortic smooth muscle of the vitamin A-deficient rat that may be associated with a down regulation in the expression of contractile-related proteins.
机译：在70日龄的维生素A缺乏型大鼠中评估了选定的心血管功能参数。静息心率平均提高100 bpm（21.4 +/- 2.7％），而维生素A缺乏动物的静息收缩压正常。维生素A缺乏的动物切除主动脉环后，每毫克组织所产生的最大收缩力会因高钾（-25.0 +/- 8.7％）和佛波醇12,13-二丁酸酯（-36.8 +/- 8.4）而降低％），但对去甲肾上腺素的响应仅略有降低（-17.8 +/- 11.1％）。内膜摩擦去除内皮对收缩反应性的丧失没有影响，并且对照组和维生素A缺乏组织组对乙酰胆碱的松弛反应相似。这表明缺乏维生素A的大鼠血管平滑肌收缩力的降低与内皮源性血管活性因子释放的改变无关。 Western blot分析表明，几种分化标记物的蛋白质水平降低，包括α-肌动蛋白（-22％），钙蛋白（-37％），结蛋白（-37％）和纽蛋白（-40％），而PKCalpha从控制值不变。我们的发现表明，维生素A缺乏症大鼠的主动脉平滑肌收缩反应能力显着降低，这可能与收缩相关蛋白表达的下调有关。

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