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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Estrogen replacement stimulates fatty acid oxidation and impairs post-ischemic recovery of hearts from ovariectomized female rats.
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Estrogen replacement stimulates fatty acid oxidation and impairs post-ischemic recovery of hearts from ovariectomized female rats.

机译：雌激素替代会刺激脂肪酸氧化并损害卵巢切除的雌性大鼠缺血后心脏的恢复。

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摘要

Women less than 50 years of age, the majority of whom are likely premenopausal and exposed to estrogen, are at greater risk of a poor short-term recovery after myocardial ischemia than men and older women. Since estrogen enhances non-cardiac lipid utilization and increased lipid utilization is associated with poor post-ischemic heart function, we determined the effect of estrogen replacement on post-ischemic myocardial function and fatty acid oxidation. Female Sprague-Dawley rats, either intact (n = 15) or ovariectomized and treated with 17beta-estradiol (0.1 mg x kg(-1) x day(-1), s.c., n = 14) or corn oil vehicle (n = 16) for 5 weeks, were compared. Function and fatty acid oxidation of isolated working hearts perfused with 1.2 mM [9,10-3H]palmitate, 5.5 mM glucose, 0.5 mM lactate, and 100 mU/L insulin were measured before and after global no-flow ischemia. Only 36% of hearts from estrogen-treated rats recovered after ischemia compared with 56% from vehicle-treated rats (p > 0.05, not significant), while 93% of hearts from intact rats recovered (p < 0.05). Relative to pre-ischemic values, post-ischemic function of estrogen-treated hearts (26.3 +/- 10.1%) was significantly lower than vehicle-treated hearts (53.4 +/- 11.8%, p < 0.05) and hearts from intact rats (81.9 +/- 7.0%, p < 0.05). Following ischemia, fatty acid oxidation was greater in estrogen-treated hearts than in the other groups. Thus, estrogen replacement stimulates fatty acid oxidation and impairs post-ischemic recovery of isolated working hearts from ovariectomized female rats.
机译：年龄小于50岁的女性，其大多数可能在绝经前并暴露于雌激素，与男性和老年女性相比，心肌缺血后短期恢复不良的风险更大。由于雌激素增强非心脏脂质利用，并且脂质利用增加与缺血后心脏功能差有关，因此我们确定了雌激素替代对缺血后心肌功能和脂肪酸氧化的影响。 Sprague-Dawley雌性大鼠，完整（n = 15）或卵巢切除并用17β-雌二醇（0.1 mg x kg（-1）x day（-1），sc，n = 14）或玉米油媒介物（n = 16）5周，进行比较。在未进行全血流缺血之前和之后，分别测量了分别灌注了1.2 mM [9,10-3H]棕榈酸酯，5.5 mM葡萄糖，0.5 mM乳酸和100 mU / L胰岛素的离体工作心脏的功能和脂肪酸氧化。缺血后，只有36％的雌激素治疗的大鼠心脏恢复，相比之下，用赋形剂治疗的大鼠的心脏恢复了56％（p> 0.05，无显着性），而完整大鼠的心脏则恢复了93％（p <0.05）。相对于缺血前值，雌激素治疗的心脏（26.3 +/- 10.1％）的缺血后功能显着低于溶媒治疗的心脏（53.4 +/- 11.8％，p <0.05）和来自完整大鼠的心脏（ 81.9 +/- 7.0％，p <0.05）。缺血后，经雌激素治疗的心脏中的脂肪酸氧化程度高于其他组。因此，雌激素替代会刺激脂肪酸氧化并损害卵巢切除雌性大鼠离体工作心脏的缺血后恢复。

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