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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Intracardiac iron distribution in newborn guinea pigs following isolated and combined fetal hypoxemia and fetal iron deficiency.
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Intracardiac iron distribution in newborn guinea pigs following isolated and combined fetal hypoxemia and fetal iron deficiency.

机译：胎儿低氧血症和胎儿缺铁合并后的新生豚鼠心内铁分布。

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摘要

Myocardial iron deficiency complicates chronic intrauterine hypoxemia during diabetic pregnancies. To understand the effect of both conditions during fetal life on intracardiac iron prioritization, we measured heart myoglobin, cytochrome c, and elemental iron concentrations in six iron-deficient, hypoxic, five iron-sufficient, hypoxic, six iron-deficient, normoxic, and six iron-sufficient, normoxic newborn guinea pigs. The iron-deficient, hypoxic group had lower heart iron (p = 0.03) but higher myoglobin concentration (p < 0.0001) when compared with the iron-sufficient, normoxic group. The percentage of iron incorporated into myoglobin was higher than control in the iron-deficient, hypoxic group (23.2+/-7.2% vs. 5.2+/-0.8%; p < 0.001) and increased as total heart iron decreased (r = 0.97; p < 0.001). In contrast, heart cytochrome c concentration was lower than control in the iron-deficient, hypoxic group (p = 0.01), with equal percentages of heart iron incorporated into cytochrome c. This intracellular prioritization of myocardial iron to myoglobin and away from cytochrome c following combined fetal hypoxemia and iron deficiency may represent an adaptive mechanism to preserve myocardial tissue oxygenation, although at the expense of oxidative phosphorylative capability.
机译：糖尿病妊娠期间心肌铁缺乏使慢性宫内低氧血症复杂化。为了了解胎儿生命中这两种状况对心内铁优先级的影响，我们测量了六个缺铁，缺氧，五个缺铁，缺氧，六个缺铁，正氧和缺铁的心脏肌红蛋白，细胞色素c和元素铁浓度。六只铁充足的常氧新生豚鼠。与缺铁的常氧组相比，缺铁的低氧组的心脏铁含量较低（p = 0.03），但肌红蛋白浓度较高（p <0.0001）。缺铁缺氧组的肌红蛋白中铁的百分比高于对照组（23.2 +/- 7.2％vs. 5.2 +/- 0.8％; p <0.001），并且随着总心脏铁减少而增加（r = 0.97） ; p <0.001）。相反，缺铁缺氧组的心脏细胞色素c浓度低于对照组（p = 0.01），其中相等百分比的心脏铁掺入细胞色素c中。胎儿低氧血症和铁缺乏症合并后，心肌中铁的优先顺序为肌红蛋白和远离细胞色素c，这可能代表了一种保护心肌组织氧合的适应性机制，尽管是以氧化磷酸化能力为代价的。

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