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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The value of studying gene-environment interactions in culturally diverse populations.
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The value of studying gene-environment interactions in culturally diverse populations.

机译：研究文化多样性人群中基因与环境相互作用的价值。

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摘要

Cardiovascular disease (CVD) is the leading cause of death and disability in the world. It is anticipated that CVD will reach pandemic proportions by the year 2020. Although the major causes of CVD are well documented and explain the majority of cardiovascular deaths, the prevalence of conventional cardiovascular risk factors vary substantially across diverse cultural groups. These differences are attributed to cultural or genetic differences or to interactions between genes and environmental factors. Substantial efforts have been invested in determining the genetic influences on CVD development, and it is unlikely that a single gene is responsible for the development of atherosclerotic CVD or its classical risk factors such as blood pressure or plasma lipids. It is more plausible that multiple genes, acting either alone or in concert with one another, which display effect modification in the presence of certain environmental factors, are modestly associated with CVD or its main risk factors. Followingthis hypothesis, studying populations with diversity in environmental factors may increase the discovery potential of gene-environmental interactions. In this brief review, the advantage of studying gene-environment interactions across heterogeneous groups with diverse lifestyles is discussed.
机译：心血管疾病（CVD）是世界上导致死亡和残疾的主要原因。预计到2020年CVD将达到大流行的比例。尽管CVD的主要原因已得到充分记录并能解释大多数心血管疾病的死亡，但传统的心血管疾病危险因素在不同的文化群体中普遍存在差异。这些差异归因于文化或遗传差异或基因与环境因素之间的相互作用。已经投入大量努力来确定遗传因素对CVD发育的影响，并且单个基因不太可能导致动脉粥样硬化CVD或其经典危险因素（如血压或血浆脂质）的发展。更有可能的是，在某些环境因素的存在下表现出作用改变的多个基因，单独或彼此协同作用，适度地与CVD或其主要危险因素相关。根据这一假设，研究环境因素具有多样性的种群可能会增加发现基因与环境相互作用的潜力。在这篇简短的综述中，讨论了研究具有不同生活方式的异类群体之间的基因-环境相互作用的优势。

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