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首页> 外文期刊>Medical image analysis >Automatic carotid artery distensibility measurements from CTA using nonrigid registration
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Automatic carotid artery distensibility measurements from CTA using nonrigid registration

机译：使用非刚性套准从CTA自动测量颈动脉可扩张性

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摘要

The distensibility of a blood vessel is a marker of atherosclerotic disease. In this paper we investigate the feasibility of measuring carotid artery distensibility on 4D CTA, both manually and using a new automatic method. On 4D CTA datasets manual (n= 38) and automatic (n= 76) measurements of the carotid distensibility were performed. A subset (n= 10) of the manual annotations were repeated by a second observer. The interobserver variability was assessed using a Bland-Altman analysis and appeared to be too large to reliably measure the distensibility using manual annotation. We compared two versions of the automatic method: one using 3D registration and one using a 4D registration method. The latter resulted in a more smooth deformation over time. The automatic method was evaluated using a synthetic deformation and by investigating whether known relations with cardiovascular risk factors could be reproduced. The relation between distensibility and cardiovascular risk factors was tested with a Mann-Whitney U test. Automatic measurements revealed an association with hypertension whereas the manual measurements did not. This relation has been found by other studies too. We conclude that carotid artery distensibility measurements should be performed automatically and that the method described in this paper is suitable for that.
机译：血管的可扩张性是动脉粥样硬化疾病的标志。在本文中，我们调查了手动和使用新的自动方法在4D CTA上测量颈动脉可扩张性的可行性。在4D CTA数据集上，进行了手动（n = 38）和自动（n = 76）的颈动脉扩张性测量。第二个观察者重复了手动注释的子集（n = 10）。观察者间的变异性使用Bland-Altman分析进行评估，似乎太大而无法使用手动注释可靠地测量可扩张性。我们比较了自动方法的两种版本：一种使用3D配准，一种使用4D配准。后者导致随时间推移更平滑的变形。使用合成变形并研究是否可以重现与心血管危险因素的已知关系来评估自动方法。使用Mann-Whitney U检验对可扩张性与心血管危险因素之间的关系进行了检验。自动测量显示与高血压有关，而手动测量则与高血压无关。其他研究也发现了这种关系。我们得出结论，应该自动执行颈动脉可扩张性测量，并且本文所述的方法适用于此。

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