Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis

Dan Zhao; Huayong Liu; Likang Zheng; Guozhen He; Di Qu; Shiqing Han

首页> 外文期刊>Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents >Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis

【24h】

Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis

机译：新型4-噻唑烷酮衍生物作为抗耐药性表皮葡萄球菌的抗菌剂的合成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A series of novel substituted 4-thiazolidione derivatives were designed, synthesized, and evaluated in vitro for their antibacterial activities, in comparison with methicillin and ampicillin. Compounds (7d, 7h-k) exhibit good potency in inhibiting the growth of Staphylococcus epidermidis (MIC: 1.57-3.13 muM). Further antibacterial effects of compounds (7d, 7h-k) were investigated using clinical isolates (methicillin-resistant Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus), in comparison with methicillin and levofloxacin. Compound 7k showed the most potent antibacterial activities among the synthesized compounds.

机译：与甲氧西林和氨苄青霉素相比，设计，合成了一系列新颖的取代的4-噻唑烷酮衍生物，并在体外评估了它们的抗菌活性。化合物（7d，7h-k）在抑制表皮葡萄球菌（MIC：1.57-3.13μM）的生长中表现出良好的效力。与甲氧西林和左氧氟沙星相比，使用临床分离株（耐甲氧西林的表皮葡萄球菌和耐甲氧西林的金黄色葡萄球菌）研究了化合物（7d，7h-k）的进一步抗菌作用。在合成的化合物中，化合物7k显示出最有效的抗菌活性。

著录项

来源
《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 |2013年第8期|共8页
作者
Dan Zhao; Huayong Liu; Likang Zheng; Guozhen He; Di Qu; Shiqing Han;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
4-Thiazolidione; Methicillin-resistant Staphylococcus epidermidis; Methicillin-resistant Staphylococcus aureus; Antibacterial activity;

机译：4-噻唑烷酮;耐甲氧西林表皮葡萄球菌;耐甲氧西林金黄色葡萄球菌;抗菌活性;

相似文献

外文文献
中文文献
专利

1. Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis [J] . Dan Zhao, Huayong Liu, Likang Zheng, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2013,第8期

机译：新型4-噻唑烷酮衍生物作为抗耐药性表皮葡萄球菌的抗菌剂的合成
2. Phenazine antibiotic inspired discovery of potent bromophenazine antibacterial agents against Staphylococcus aureus and Staphylococcus epidermidis [J] . Nicholas V. Borrero, Fang Bai, Cristian Perez, Organic & biomolecular chemistry . 2014,第6期

机译：吩嗪抗生素激发了针对金黄色葡萄球菌和表皮葡萄球菌的有效溴苯那嗪抗菌剂的发现
3. Function-oriented synthesis of simplified caprazamycins: Discovery of oxazolidine-containing uridine derivatives as antibacterial agents against drug-resistant bacteria [J] . Ii K., Ichikawa S., Al-Dabbagh B., Journal of Medicinal Chemistry . 2010,第9期

机译：简化的辣椒素霉素的功能导向合成：发现含恶唑烷的尿苷衍生物作为抗耐药细菌的抗菌剂
4. RAPID AND EFFICIENT MICROWAVE ASSISTED SYNTHESIS OF SOME NEW 3-(4-AMINO-5-THIOXO-1,2,4-TRIAZOL-3-YL)METHYL-1,3-BENZOTHIAZOL-2-ONE DERIVATIVES AS ANTIBACTERIAL AGENTS [C] . Yasemin Dundar, M. Fethi Sahin, Tijen Onkol European Symposium on Organic Chemistry . 2009

机译：快速高效的微波辅助合成一些新的3 - （4-氨基-5-硫代-1,2,4-三唑-3-基）甲基 -1,3-苯并噻唑-2-一种衍生物作为抗菌剂
5. Class III phase variation in Staphylococcus epidermidis: Staphylococcus epidermidis icaADBC(+) and icaADBC(-) human skin colonization: The Staphylococcus epidermidis two-component regulatory system sae . [D] . Rogers, Kathie L. 2008

机译：表皮葡萄球菌的III类相变：表皮葡萄球菌icaADBC（+）和icaADBC（-）人皮肤定植：表皮葡萄球菌两组分调节系统sae。
6. Design and synthesis of an indol derivative as antibacterial agent against Staphylococcus aureus [O] . Hau-Heredia Lenin, Figueroa-Valverde Lauro, Rosas-Nexticapa Marcela, 2009

机译：吲哚衍生物作为金黄色葡萄球菌抗菌剂的设计与合成
7. Synthesis of Novel Methoxy Substituted Benzothiazole Derivatives and Antibacterial Activity against Staphylococcus epidermidis [O] . Akhilesh Gupta 2018

机译：新甲氧基取代苯并噻唑衍生物的合成及对葡萄球菌癫痫的抗菌活性
8. Epidemiologic Features and Phage Types Associated with Nosocomial Infections Caused by Staphylococcus epidermidis (Epidemiologische Merkmale und Phagtypen bei Krankenhausinfektionen durch Staphylococcus epidermidis). [R] . Blouse, L. E., Lathrop, G. D., Kolonel, L. N., 1978

机译：与表皮葡萄球菌（Epidemiologische merkmale und phagtypen bei Krankenhausinfektionen durch staphylococcus epidermidis）引起的医院感染相关的流行病学特征和噬菌体类型。

Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis

摘要

著录项

相似文献

相关主题

期刊订阅