Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

LiangJ.; NagahashiM.; KimE.Y.; HarikumarK.B.; YamadaA.; HuangW.-C.; HaitN.C.; AllegoodJ.C.; PriceM.M.; AvniD.; TakabeK.; KordulaT.; MilstienS.; SpiegelS.

首页> 外文期刊>Cancer Cell >Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

【24h】

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

机译：鞘氨醇-1-磷酸链接持久的STAT3激活，慢性肠道炎症和结肠炎相关的癌症的发展。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Inflammatory bowel disease is an important risk factor for colorectal cancer. We show that sphingosine-1-phosphate (S1P) produced by upregulation of sphingosine kinase 1 (SphK1) links chronic intestinal inflammation to colitis-associated cancer (CAC) and both are exacerbated by deletion of Sphk2. S1P is essential for production of the multifunctional NF-κB-regulated cytokine IL-6, persistent activation of the transcription factor STAT3, and consequent upregulation of the S1P receptor, S1PR1. The prodrug FTY720 decreased SphK1 and S1PR1 expression and eliminated the NF-κB/IL-6/STAT3 amplification cascade and development of CAC, even in Sphk2-/- mice, and may be useful in treating colon cancer in individuals with ulcerative colitis. Thus, the SphK1/S1P/S1PR1 axis is at the nexus between NF-κB and STAT3 and connects chronic inflammation and CAC.

机译：炎症性肠病是结直肠癌的重要危险因素。我们显示鞘氨醇激酶1（SphK1）的上调产生的鞘氨醇-1-磷酸（S1P）链接慢性肠炎与结肠炎相关的癌症（CAC），并且都通过删除Sphk2加剧。 S1P对于多功能NF-κB调节的细胞因子IL-6的产生，转录因子STAT3的持续激活以及随后的S1P受体S1PR1的上调至关重要。前药FTY720降低了SphK1和S1PR1的表达，并消除了NF-κB/ IL-6 / STAT3扩增级联和CAC的形成，甚至在Sphk2-/-小鼠中也可能有用，可用于治疗溃疡性结肠炎患者的结肠癌。因此，SphK1 / S1P / S1PR1轴位于NF-κB和STAT3之间，并连接慢性炎症和CAC。

著录项

来源
《Cancer Cell》 |2013年第1期|共14页
作者
LiangJ.; NagahashiM.; KimE.Y.; HarikumarK.B.; YamadaA.; HuangW.-C.; HaitN.C.; AllegoodJ.C.; PriceM.M.; AvniD.; TakabeK.; KordulaT.; MilstienS.; SpiegelS.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词

相似文献

外文文献
中文文献
专利

1. Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer [J] . LiangJ., NagahashiM., KimE.Y., Cancer Cell . 2013,第1期

机译：鞘氨醇-1-磷酸链接持久的STAT3激活，慢性肠道炎症和结肠炎相关的癌症的发展。
2. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. [J] . Grivennikov S, Karin E, Terzic J, Cancer Cell . 2009,第2期

机译：IL-6和Stat3是肠道上皮细胞存活和结肠炎相关癌症发展所必需的。
3. Sphingosine-1-phosphate in chronic intestinal inflammation and cancer [J] . NagahashiM., HaitN.C., MaceykaM., Advances in biological regulation . 2014,第Null期

机译：1-磷酸鞘氨醇在慢性肠炎和癌症中的作用
4. Over-activation of the stat3 pathway in lung epithelial cells induces pulmonary inflammation and lung cancer [C] . Liu Yujie, rnPiao Linhua, rnSong Jia, Journal of Organ Dysfunction: ISRD 2007 Abstract Book . 2007

机译：肺上皮细胞中stat3通路的过度激活引起肺部炎症和肺癌
5. Colonic epithelial genes in the transition from chronic inflammation to carcinoma in human colitis-associated cancer: Focus on the truncated neurokinin-1 receptor. [D] . Gillespie, Earl. 2013

机译：在人类结肠炎相关癌症中，从慢性炎症过渡到癌变过程中的结肠上皮基因：关注截短的神经激肽1受体。
6. Sphingosine-1-Phosphate Links Persistent STAT3 Activation Chronic Intestinal Inflammation and Development of Colitis-Associated Cancer [O] . Jie Liang, Masayuki Nagahashi, Eugene Y. Kim, -1

机译：鞘氨醇-1-磷酸永久链接激活sTaT3慢性肠道炎症和结肠炎相关癌症的发展
7. Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer [O] . Liang Jie, Nagahashi Masayuki, Kim Eugene Y., 2013

机译：鞘氨醇-1-磷酸链接持久的STAT3激活，慢性肠道炎症和结肠炎相关的癌症的发展。

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

摘要

著录项

相似文献

相关主题

期刊订阅