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Lipids in cell biology:how can we understand them better?

机译:细胞生物学中的脂质:如何更好地理解它们?

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摘要

Lipids are a major class of biological molecules and play many key roles in different processes. The diversity of lipids is on the same order of magnitude as that of proteins:cells express tens of thousands of different lipids and hundreds of proteins to regulate their metabolism and transport. Despite their clear importance and essential functions, lipids have not been as well studied as proteins. We discuss here some of the reasons why it has been challenging to study lipids and outline technological developments that are allowing us to begin lifting lipids out of their "Cinderella" status. We focus on recent advances in lipid identification, visualization, and investigation of their biophysics and perturbations and suggest that the field has sufficiently advanced to encourage broader investigation into these intriguing molecules.
机译:脂质是生物分子的主要类别,在不同的过程中起许多关键作用。脂质的多样性与蛋白质的多样性处于同一数量级:细胞表达成千上万种不同的脂质和数百种蛋白质来调节其代谢和运输。尽管它们具有明显的重要性和基本功能,但对脂质的研究却不如蛋白质。我们在这里讨论研究脂质的挑战并概述允许其开始将脂质从“灰姑娘”状态中解脱出来的技术发展的一些原因。我们关注脂质鉴定,可视化以及它们的生物物理和扰动研究的最新进展,并建议该领域已经取得了足够的进步,以鼓励对这些引人入胜的分子进行更广泛的研究。

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