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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >ON THE CYTOTOXICITY AND GENOTOXICITY OF ALLYL AND PHENETHYL ISOTHIOCYANATES AND THEIR PARENT GLUCOSINOLATES SINIGRIN AND GLUCONASTURTIIN
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ON THE CYTOTOXICITY AND GENOTOXICITY OF ALLYL AND PHENETHYL ISOTHIOCYANATES AND THEIR PARENT GLUCOSINOLATES SINIGRIN AND GLUCONASTURTIIN

机译：烯丙基和苯甲基异硫氰酸酯及其父本葡糖胞苷芥子素和葡糖醛固素的细胞毒性和遗传毒性

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摘要

Four compounds commonly found in the human diet, allyl isothiocyanate (AITC), phenethyl isothiocyanate (PEITC) and their parent glucosinolates sinigrin and gluconasturtiin, were tested for cytotoxic and genotoxic effects in a Chinese hamster ovary cell line (CHO). The isothiocyanates were found to be more than one thousand times more cytotoxic than the glucosinolates,: showing significant cytotoxic activity at concentrations below 1.0 mu g/ml. AITC was unable to induce either chromosome aberrations or sister chromatid exchanges (SCEs) even at highly cytotoxic doses. In contrast, PEITC was found to induce both aberrations and SCE at concentrations of 0.9-1.2 mu g/ml whilst sinigrin and gluconasturtiin induced aberrations at concentrations above 2 mg/ml.
机译：测试了人类饮食中常见的四种化合物异硫氰酸烯丙酯（AITC），异硫氰酸苯乙基酯（PEITC）及其母体硫代芥子油苷芥子苷和葡糖松香苷在中国仓鼠卵巢细胞系（CHO）中的细胞毒性和遗传毒性作用。发现异硫氰酸酯的细胞毒性比芥子油苷高出一千倍以上：在浓度低于1.0μg/ ml时显示出显着的细胞毒活性。即使在高细胞毒性剂量下，AITC也无法诱导染色体畸变或姐妹染色单体交换（SCE）。相比之下，发现PEITC在0.9-1.2μg / ml的浓度下会引起畸变和SCE，而在3 mg / ml以上的浓度下，芥子苷和葡糖松香苷会引起畸变。

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