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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >ADRIAMYCIN-INDUCIBLE PROTEINS ASSOCIATED WITH DRUG SENSITIVITY IN RESISTANT IMMUNOBLASTIC B LYMPHOMA CELLS
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ADRIAMYCIN-INDUCIBLE PROTEINS ASSOCIATED WITH DRUG SENSITIVITY IN RESISTANT IMMUNOBLASTIC B LYMPHOMA CELLS

机译：耐药性免疫性B淋巴瘤细胞中阿霉素诱导的蛋白质与药物敏感性的关系

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We have previously established an immunoblastic B lymphoma cell line, designated HOB1. This cell line is hypersensitive to a wide spectrum of chemotherapeutic agents. Two co-regulated polypeptides around 64 kDa (termed p64) were induced 10-30-fold in response to adriamycin and some other drugs at the IC50 (the concentration inhibiting cell growth by 50%). These inducible proteins are localized as monomeric forms in the cytosolic fraction, with isoelectric points of pH = 6.2 (major protein) and pH = 7.0 (minor protein). An adriamycin-resistant cell line was established from HOB1 cells. The p64 inducibility was dramatically reduced in resistant HOB1 cells or unrelated cell lines which show phenotypic resistance to adriamycin toxicity. The loss of p64 inducibility in resistant cells is not due to a failure of cells to take up adriamycin since drug accumulation kinetics remained the same as in the parental cells.
机译：我们先前已经建立了一种免疫原性B淋巴瘤细胞系，命名为HOB1。该细胞系对广泛的化学治疗剂高度敏感。在IC50（浓度抑制细胞生长50％）时，对阿霉素和其他一些药物的反应，诱导了两个约64 kDa的共调控多肽（称为p64）被诱导10-30倍。这些可诱导的蛋白质以单体形式定位在胞质级分中，等电点的pH = 6.2（主要蛋白质）和pH = 7.0（次要蛋白质）。从HOB1细胞建立抗阿霉素的细胞系。在耐药的HOB1细胞或不相关的细胞系中，p64的诱导能力显着降低，它们对阿霉素毒性表现出表型抵抗力。抗药性细胞中p64诱导能力的丧失不是由于细胞不能摄取阿霉素，因为药物的累积动力学与亲代细胞相同。

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