Label-free optical detection and tracking of single virions bound to their receptors in supported membrane bilayers

Ewers H; Jacobsen V; Klotzsch E; Smith AE; Helenius A; Sandoghdar V

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Label-free optical detection and tracking of single virions bound to their receptors in supported membrane bilayers

机译：无标记的光学检测和跟踪结合在支持膜双层中与其受体结合的单个病毒体

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We apply an interferometric optical detection scheme to image and track unlabeled single virions. Individual simian virus 40 virions and uninfectious virus-like particles were imaged on a glass substrate and on a supported membrane bilayer. Moreover, single unlabeled virions were tracked when bound to supported membrane bilayers via the viral receptor, the glycolipid GM1. The technology presented here promises to be generally applicable to studying the motion of unlabeled macromolecules on membranes.

机译：我们将干涉光学检测方案应用于图像和跟踪未标记的单个病毒体。将单个猿猴病毒40病毒体和非感染性病毒样颗粒成像在玻璃基板和支撑的双层膜上。此外，当通过病毒受体糖脂GM1与支持的膜双层结合时，可以追踪单个未标记的病毒粒子。本文介绍的技术有望普遍应用于研究膜上未标记的大分子的运动。

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《Nano letters》 |2007年第8期|共4页
作者
Ewers H; Jacobsen V; Klotzsch E; Smith AE; Helenius A; Sandoghdar V;
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正文语种 eng
中图分类特种结构材料;
关键词
MURINE POLYOMA-VIRUS; BROWNIAN-MOTION; LIVE CELLS; RESOLUTION; PARTICLES; NANOPARTICLES; GANGLIOSIDE; ENDOCYTOSIS; MOBILITY; PATHWAY;

机译：小鼠多动症病毒;布朗运动;活细胞;分辨率;颗粒;纳米颗粒;神经节苷脂;内吞;流动性;途径;

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1. Label-free optical detection and tracking of single virions bound to their receptors in supported membrane bilayers [J] . Ewers H, Jacobsen V, Klotzsch E, Nano letters . 2007,第8期

机译：无标记的光学检测和跟踪结合在支持膜双层中与其受体结合的单个病毒体
2. "Waltz" of Cell Membrane-Coated Nanoparticles on Lipid Bilayers: Tracking Single Particle Rotation in Ligand-Receptor Binding [J] . Yu Yanqi, Gao Yuan, Yu Yan ACS nano . 2018,第12期

机译：细胞膜涂层纳米颗粒上的“华尔兹”在脂质双层上的纳米颗粒：跟踪配体 - 受体结合中的单颗粒旋转
3. Exploring in vivo cholesterol-mediated interactions between activated EGF receptors in plasma membrane with single-molecule optical tracking [J] . Chien Y. Lin, Jung Y. Huang, Leu-Wei Lo BMC Biophysics . 2016,第1期

机译：用单分子光学跟踪探索体内胆固醇介导的活化EGF受体之间的相互作用。
4. Single molecule tracking and spectroscopy unveils molecular details in function and interactions of membrane receptors [C] . Laura Marchetti, Fulvio Bonsignore, Rosy Amodeo, Conference on Single Molecule Spectroscopy and Superresolution Imaging . 2021

机译：单分子跟踪和光谱揭示膜受体的功能和相互作用中的分子细节
5. Label-Free Detection of Single Biological Molecules Using Microtoroid Optical Resonators. [D] . Su, Judith. 2014

机译：使用微环型光学谐振器对单个生物分子进行无标签检测。
6. Label-Free All-Optical Detection Imaging and Trackingof a Single Protein [O] . J. Ortega Arroyo, J. Andrecka, K. M. Spillane, -1

机译：无标签全光检测成像和跟踪单一蛋白质
7. Label-Free Optical Detection and Tracking of Single Virions Bound to Their Receptor in Supported Membrane Bilayers [O] . -1

机译：无标记的光学检测和跟踪在负载的膜双层中与其受体结合的单个病毒粒

Label-free optical detection and tracking of single virions bound to their receptors in supported membrane bilayers

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