Antigen-specific CD4(+) regulatory T cells in cancer: implications for immunotherapy

Wang HY; Wang RF

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Antigen-specific CD4(+) regulatory T cells in cancer: implications for immunotherapy

机译：癌症中的抗原特异性CD4（+）调节性T细胞：对免疫疗法的影响

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Regulatory T cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Despite the importance of CD4(+) regulatory T cells in many immune-related diseases, their antigen specificity and suppressive mechanisms remain elusive. This review discusses the natural ligands and their potential roles of tumor-specific CD4(+) regulatory T cells in cancer therapy. (c) 2005 Elsevier SAS. All rights reserved.

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《Microbes and infection》 |2005年第8期|共7页
作者
Wang HY; Wang RF;
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正文语种 eng
中图分类细胞生物学;
关键词
cancer vaccines; CD4(+) lymphocytes; Foxp3; immune suppression; immunotherapy; regulatory T cells; tumor immunology; IMMUNOLOGICAL SELF-TOLERANCE; TRANSCRIPTION FACTOR FOXP3; HUMAN DENDRITIC CELLS; GROWTH-FACTOR-BETA; IN-VIVO; TUMOR-IMMUNITY; CONTROLLING AUTOIMMUNITY; AIRWAY HYPERREACTIVITY; MEDIATED SUPPRESSION; CD8-T-CELL MEMORY;

机译：癌症疫苗;CD4（+）淋巴细胞;Foxp3;免疫抑制;免疫治疗;调节性T细胞;肿瘤免疫学;免疫学自耐受性;转录因子FOXP3;人类树突状细胞;生长因子-BETA;体内;体内;肿瘤-免疫控制自主性;气道高反应性;介导的抑制;CD8-T细胞记忆;

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专利

1. Antigen-specific CD4(+) regulatory T cells in cancer: implications for immunotherapy [J] . Wang HY, Wang RF Microbes and infection . 2005,第7a8期

机译：癌症中的抗原特异性CD4（+）调节性T细胞：对免疫疗法的影响
2. Long peptide-based cancer immunotherapy targeting tumor antigen-specific CD4(+)and CD8(+) T cells. [J] . Tomita Y, Nishimura Y. Oncoimmunology. . 2013,第9期

机译：针对肿瘤抗原特异性CD4（+）和CD8（+）T细胞的基于长肽的癌症免疫疗法。
3. CD59 Blockade Enhances Antigen-Specific CD4+ T Cell Responses in Humans: A New Target for Cancer Immunotherapy? [J] . Baalasubramanian Sivasankar, M. Paula Longhi, Kathleen M. E. Gallagher, The journal of immunology . 2009,第9期

机译：CD59阻断增强人类抗原特异性CD4 + T细胞反应：癌症免疫疗法的新目标吗？
4. Selective capture of regulatory T cells for cancer immunotherapy [C] . Tsuyoshi Kimura, Naoko Nakamura, Yoshihide Hashimoto, Society for Biomaterials annual meeting and exposition . 2017

机译：选择性捕获调节性T细胞用于癌症免疫治疗
5. TGF-beta and cancer development: The role of TGF-beta in converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells and a TbetaRIIDN-tk/ganciclovir suicide system in cancer gene therapy [D] . Liu, Victoria Chunyan 2007

机译：TGF-β与癌症的发展：TGF-β在将CD4 + CD25-T细胞转化为CD4 + CD25 + T调节细胞以及TbetaRIIDN-tk /更昔洛韦自杀系统中的作用
6. Long peptide-based cancer immunotherapy targeting tumor antigen-specific CD4+ and CD8+ T cells [O] . Yusuke Tomita, Yasuharu Nishimura 2013

机译：针对肿瘤抗原特异性CD4 +和CD8 + T细胞的基于长肽的癌症免疫疗法
7. The Wilms ’ Tumor Antigen Is a Novel Target for Human CD4 + Regulatory T Cells: Implications for Immunotherapy [O] . Cynthia Lehe, Hazem Ghebeh, Abdullah Al-sulaiman, 2008

机译：Wilms的肿瘤抗原是人类CD4 +调节性T细胞的新型靶标：对免疫疗法的意义
8. Antigen-Specific Immunotherapy Using Lentivirus-Transduced Hematopoietic Progenitor Cell: A Novel Approach for the Treatment of Metastatis Prostate Cancer [R] . Cheng, L. 2004

机译：使用慢病毒转导的造血祖细胞进行抗原特异性免疫治疗：一种治疗转移性前列腺癌的新方法

Antigen-specific CD4(+) regulatory T cells in cancer: implications for immunotherapy

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