T cell development: better living through chromatin

Krangel MS

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T cell development: better living through chromatin

机译：T细胞发育：通过染色质改善生活

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T lymphocyte development is directed by a gene-expression program that occurs in the complex nucleoprotein environment of chromatin. This review examines basic principles of chromatin regulation and evaluates ongoing progress toward understanding how the chromatin template is manipulated to control gene expression and gene recombination in developing thymocytes. Special attention is devoted to the loci encoding T cell receptors alpha and beta, T cell coreceptors CD4 and CD8, and the enzyme terminal deoxynucleotidyl transferase. The properties of SATB1, a notable organizer of thymocyte chromatin, are also addressed.

机译：T淋巴细胞的发育由在染色质的复杂核蛋白环境中发生的基因表达程序控制。这篇综述审查了染色质调节的基本原理，并评估了在了解如何操纵染色质模板以控制发育中的胸腺细胞中的基因表达和基因重组方面的不断进步。特别注意编码T细胞受体α和β，T细胞共受体CD4和CD8以及酶末端脱氧核苷酸转移酶的基因座。还介绍了SATB1（胸腺细胞染色质的重要组织者）的特性。

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《Nature immunology》 |2007年第7期|共8页
作者
Krangel MS;
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正文语种 eng
中图分类基础医学;
关键词
CD4/CD8 LINEAGE CHOICE; HEAVY-CHAIN GENE; ALLELIC EXCLUSION; V(D)J RECOMBINATION; NUCLEAR-ORGANIZATION; HISTONE ACETYLATION; LYMPHOCYTE DEVELOPMENT; THYMOCYTE DEVELOPMENT; GENOMIC ORGANIZATION; SILENT CHROMATIN;

机译：CD4 / CD8谱系选择;重链基因;等位基因排斥;V（D）J重组;核组织;组氨酸乙酰化;淋巴细胞发育;胸腺细胞发育;基因组学;沉默的染色质;

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1. Rapid Exchange of Histone H1.1 on Chromatin in Living Human Cells Dynamic Binding of Histone H1 to Chromatin in Living Cells [J] . M. A. Lever, J. P. H. Thng, X. Sun, Chemtracts . 2001,第13期

机译：组蛋白H1.1在活细胞中染色质上的快速交换组蛋白H1与活细胞中染色质的动态结合
2. T cell development: better living through chromatin [J] . Krangel MS Nature immunology . 2007,第7期

机译：T细胞发育：通过染色质改善生活
3. Chromatin conformation in living cells: Support for a zig-zag model of the 30 nm chromatin fiber [J] . Rydberg B., Mian IS., Chatterjee A., Journal of Molecular Biology . 1998,第1期

机译：活细胞中的染色质构象：支持30 nm染色质纤维的锯齿形模型
4. VISUALIZATION AT HIGH SPATIO-TEMPORAL RESOLUTION TNF ALPHA-DEPENDENT CHROMATIN REORGANIZATION IN LIVING MAMMALIAN CELLS [C] . S. Fanucchi, M. Mhlanga Annual Conference of the Microscopy Society of Southern Africa . 2012

机译：在活性哺乳动物细胞中高时α-依赖染色质重组的高时空分辨率的可视化
5. Differentiating between living and non-living prokaryotic cells: Development, evaluation, and application of a modified vital stain and probe method (mVSP). [D] . Howard-Jones, Michelle Hope. 2002

机译：区分活体和非活体原核细胞：改进的活体染色和探针法（mVSP）的开发，评估和应用。
6. 16-hexanediol rapidly immobilizes and condenses chromatin in living human cells [O] . Yuji Itoh, Shiori Iida, Sachiko Tamura, 2021

机译：16-己二醇在活人细胞中迅速固定并冷凝染色质
7. 1C1524 How can we know the chromatin environment in living cells? : Structural analysis of mitotic chromosomes in living cells(Nucleic acid,The 49th Annual Meeting of the Biophysical Society of Japan) [O] . Saera Hihara, Chang Pack, Kazunari Kaizu, 2011

机译：1C1524我们如何知道活细胞中的染色质环境？：生物细胞中有丝分裂染色体的结构分析（核酸，日本生物物理学会第49次年会）

T cell development: better living through chromatin

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