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首页> 外文期刊>Nature reviews. Nephrology >Hemodialysis: Mineral metabolism outcomes with frequent hemodialysis
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Hemodialysis: Mineral metabolism outcomes with frequent hemodialysis

机译：血液透析：血液代谢频繁的矿物质代谢

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Using an integrated computational and experimental systems biology approach, researchers have identified HIPK2 as a novel therapeutic target for kidney fibrosis. "We developed new tools that enabled us to identify upstream protein kinases responsible for altered gene expression in kidney disease," explains John He from the Mount Sinai School of Medicine.The researchers compared differentially expressed genes in the Tg26 HIV mouse model-which has both tubulointerstitial fibrosis and glomerulosclerosis-and wild-type littermates. By computationally identifying and ranking protein kinases potentially responsible for the observed changes in gene expression, HIPK2 was predicted to have an important role in HIV-associated nephropathy.
机译：使用集成的计算和实验系统生物学方法，研究人员已经确定HIPK2是肾脏纤维化的新型治疗靶标。西奈山医学院的John He解释说：“我们开发了新的工具，使我们能够识别导致肾脏疾病基因表达改变的上游蛋白激酶。”研究人员比较了Tg26 HIV小鼠模型中差异表达的基因-肾小管间质纤维化和肾小球硬化以及野生型同窝仔。通过计算鉴定和排序可能负责观察到的基因表达变化的蛋白激酶，HIPK2被预测在与HIV相关的肾病中具有重要作用。

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