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首页> 外文期刊>Neonatology >Fatal effects of a neonatal high-protein diet in low-birth-weight piglets used as a model of intrauterine growth restriction.
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Fatal effects of a neonatal high-protein diet in low-birth-weight piglets used as a model of intrauterine growth restriction.

机译：新生儿高蛋白饮食对低体重仔猪的致命影响用作子宫内生长受限模型。

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BACKGROUND: Although full-term infants suffering intrauterine growth restriction (IUGR) are routinely fed high-protein (HP) formulas to ensure catch-up growth, the effects of HP intake are poorly understood. An IUGR piglet model provides an opportunity to investigate these effects. METHODS AND RESULTS: Twelve IUGR piglets were artificially fed HP formulas (50% more protein in comparison to sow milk) from the 2nd day of life (d2) until d28. Unexpectedly, all HP piglets developed poor growth, severe hypotonia and polypnea between d10 and d16. One third died spontaneously. This syndrome was investigated to understand its pathophysiology and to adopt a strategy to restore health. Blood and urine biochemistry and amino acid concentrations were investigated in 10 HP piglets and 8 piglets that were fed a normal-protein (NP) formula. In comparison to NP piglets, HP piglets showed significant hypokalemia (2.7 +/- 0.6 vs. 3.6 +/- 0.6 mmol/l; p < 0.01), hypophosphatemia (1.5 +/- 0.2 vs. 3.0 +/- 0.3 mmol/l; p > 0.01), hypercalcemia (3.0 +/- 0.3 vs. 2.5 +/- 0.2 mmol/l; p < 0.01), hyperammonemia (365 +/- 4 vs. 242 +/- 15 micromol/l; p < 0.05), elevated blood urea (6.5 +/- 0.4 vs. 1.3 +/- 0.4 mmol/l; p < 0.01) and elevated taurine concentrations (50.2 +/- 8.5 vs. 17.7 +/- 2.7 micromol/l; p < 0.01). CONCLUSIONS: These altered parameters indicated inadequate potassium and phosphorus dietary supplies in HP piglets. When the HP formula was supplemented with monocalcium phosphate and monopotassium phosphate (HP-sup), serum biochemistry was normalized in piglets fed this formula (n = 8). This experimental strategy restored growth in IUGR piglets fed HP-sup, without a toxic effect. The current findings suggest that use of an HP formula without a proportional increase in its phosphorus and potassium content induces pathology similar to the refeeding syndrome in IUGR piglets.
机译：背景：尽管患有宫内发育受限（IUGR）的足月婴儿常规喂养高蛋白（HP）配方奶粉以确保追赶生长，但对HP摄入的影响了解甚少。 IUGR仔猪模型提供了研究这些效应的机会。方法和结果：从生命的第二天（d2）到d28，人工喂养12只IUGR仔猪HP配方食品（与母乳相比，蛋白质增加50％）。出乎意料的是，所有HP仔猪在d10至d16之间均生长不良，严重的低渗和多呼吸。三分之一自然死亡。已对该综合征进行了调查，以了解其病理生理并采取恢复健康的策略。在10头HP仔猪和8头饲喂正常蛋白（NP）配方的仔猪中研究了血液和尿液的生化及氨基酸浓度。与NP仔猪相比，HP仔猪表现出明显的低钾血症（2.7 +/- 0.6 vs. 3.6 +/- 0.6 mmol / l; p <0.01），低磷血症（1.5 +/- 0.2 vs. 3.0 +/- 0.3 mmol / l ; p> 0.01），高钙血症（3.0 +/- 0.3 vs. 2.5 +/- 0.2 mmol / l; p <0.01），高氨血症（365 +/- 4 vs. 242 +/- 15 micromol / l; p <0.05 ），血尿素含量升高（6.5 +/- 0.4 vs. 1.3 +/- 0.4 mmol / l; p <0.01）和牛磺酸浓度升高（50.2 +/- 8.5 vs. 17.7 +/- 2.7 micromol / l; p <0.01 ）。结论：这些参数改变表明HP仔猪的钾和磷日粮供应不足。当HP配方奶粉中添加了磷酸一钙和磷酸一钾（HP-sup）时，饲喂该配方奶粉的仔猪的血清生物化学正常化（n = 8）。该实验策略恢复了HP-sup喂养的IUGR仔猪的生长，而没有毒性作用。目前的发现表明，使用HP配方中的磷和钾含量没有成比例增加的情况，会引起类似于IUGR仔猪再喂养综合征的病理。

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