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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Melatonin and deprivation myopia in chickens.
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Melatonin and deprivation myopia in chickens.

机译：褪黑激素和剥夺鸡只的近视。

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摘要

Chicken eyes elongate and become myopic if they are covered with translucent diffusors which degrade the retinal image ('deprivation myopia'). Since it has been shown that dopamine D2/D4 receptors (which mediate inhibition of melatonin synthesis) are also implicated in deprivation myopia, we have studied the role of melatonin in the visual control of eye growth. We have found that (1) diurnal melatonin rhythms and melatonin content in the retina are unchanged during deprivation myopia development despite the breakdown of both diurnal growth rhythms of the eye and diurnal rhythms in retinal dopamine metabolism, (2) diurnal melatonin rhythms and melatonin content in the retina remain unchanged after application of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) and presumably also after 6-hydroxydopamine (6-OHDA) application which both have a suppressive effect on deprivation myopia and (3) deprivation myopia was slightly reduced in both eyes after unilateral intravitreal injection of melatonin, despitethat deprivation myopia is based on a mechanism intrinsic to the eye. We conclude that melatonin is not involved in the retinal signaling pathway translating visual experience to deprivation myopia.
机译：如果鸡眼被半透明的漫射器覆盖，会降低其视网膜像（“剥夺性近视”），则它们会伸长并成为近视眼。由于已显示多巴胺D2 / D4受体（介导褪黑激素合成的抑制）也与剥夺性近视有关，因此我们研究了褪黑激素在眼睛生长的视觉控制中的作用。我们发现，（1）剥夺性近视眼的视网膜昼夜褪黑素节律和褪黑素含量没有变化，尽管眼的昼夜生长节律和视网膜多巴胺代谢的昼夜节律都崩溃了;（2）昼夜褪黑素节律和褪黑激素含量使用神经毒素5,7-二羟基色胺（5,7-DHT）以及大概使用6-羟基多巴胺（6-OHDA）后，视网膜中的视网膜色素变性均保持不变，这两种物质均对剥夺性近视和（3）剥夺性近视具有抑制作用尽管剥夺性近视是基于眼睛固有的机制，但单侧玻璃体内注射褪黑激素后双眼的视力却有所降低。我们得出的结论是，褪黑激素不参与将视觉体验转化为剥夺性近视的视网膜信号通路。

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