• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Maternal dietary restriction during lactation influences postnatal growth and behavior in the offspring of mice.
【24h】

Maternal dietary restriction during lactation influences postnatal growth and behavior in the offspring of mice.

机译：哺乳期的母体饮食限制会影响小鼠后代的生长和行为。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

It is well known that maternal nutritional status is important to the development of mammalian offspring. We examined the effect of maternal food restriction during lactation on offspring in mice. From 1 to 21 days after parturition, control dams (CDs) were fed with the standard amounts of daily food consumption, whereas dietary restricted dams (RDs) received 70% of daily food consumption. Although the mean body weight of RDs was not significantly different from that of the CDs, body weight of the offspring from RD (RD offspring) was significantly lower than that of the offspring from CD (CD offspring). The difference was detectable until 10 weeks of age. Body lengths and brain weights of RD offspring at postnatal day 22 were lower than those of the CD offspring. Plasma concentrations of leptin in RD offspring decreased significantly. But plasma concentrations of growth hormone and thyroxin were not different between the two groups. In the open field tests, total distance was significantly decreased in RD offspring compared with CD offspring. In the hole-board test, head dip latency was increased and the number of dips was decreased significantly in RD offspring. In the elevated plus maze test, total distance and risk assessment were significantly decreased in the RD offspring. There was no difference between the two groups in the rota-rod and wire-hang tests. These results suggest that maternal dietary restriction during lactation can affect the growth, locomotor activity and anxiety behavior of offspring, but not motor or neuromuscular function.
机译：众所周知，母体的营养状况对哺乳动物后代的发育很重要。我们检查了哺乳期间母体食物限制对小鼠后代的影响。在分娩后的1至21天，对照水坝（CD）的食物量为每日标准摄入量，而饮食限制水坝（RDs）的食物量为每日食物量的70％。尽管RD的平均体重与CD的平均体重没有显着差异，但RD的后代（RD的后代）的体重明显低于CD的后代（CD的后代）。直到10周龄时才可以检测到差异。出生后第22天，RD后代的体长和脑重低于CD后代。 RD后代中的瘦素血浆浓度显着降低。但是两组的生长激素和甲状腺素的血浆浓度没有差异。在野外试验中，与CD后代相比，RD后代的总距离显着降低。在孔板测试中，RD后代的头部浸入潜伏期增加，浸入次数明显减少。在高架迷宫测试中，RD后代的总距离和风险评估显着降低。旋转棒和线悬挂测试的两组之间没有差异。这些结果表明，哺乳期母亲的饮食限制会影响后代的生长，运动能力和焦虑行为，但不会影响运动或神经肌肉功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号