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首页> 外文期刊>Carcinogenesis >Butyrylated starch protects colonocyte DNA against dietary protein-induced damage in rats.
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Butyrylated starch protects colonocyte DNA against dietary protein-induced damage in rats.

机译：丁基化淀粉可保护结肠细胞DNA免受饮食中蛋白质对大鼠的损害。

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摘要

Dietary resistant starch (RS), as a high amylose maize starch (HAMS), prevents dietary protein-induced colonocyte genetic damage in rats, possibly through the short-chain fatty acid (SCFA) butyrate produced by large bowel bacterial RS fermentation. Increasing butyrate availability may improve colonic health and dietary high amylose maize butyrylated starch (HAMSB) is an effective method of achieving this goal. In this study, rats (n = 8 per group) were fed diets containing high levels (25%) of dietary protein as casein with 10 or 20% dietary HAMSB and HAMS. Colonocyte genetic damage was measured by the comet assay and was 2-fold higher in rats fed 25% protein than those fed 15% protein (P < 0.001). Concurrent feeding of 25% protein and either HAMS or HAMSB lowered genetic damage significantly relative to a low-RS high-protein control diet. The 20% HAMSB diet was twice as effective as 20% HAMS in opposing genetic damage. Large bowel digesta butyrate was significantly increased in rats fed 20% compared with 10% HAMS and in rats fed 20% compared with 10% HAMSB. The levels were significantly higher in the HAMSB groups relative to the HAMS groups. Hepatic portal venous SCFA were higher in rats fed HAMS and highest in those fed HAMSB. Caecal digesta ammonia was increased by HAMSB and correlated negatively with digesta pH. Ammonia is cytotoxic and lower digesta pH could lower its absorption, possibly contributing to lower genetic damage. Delivery of butyrate to the large bowel by HAMSB could reduce colorectal cancer risk by preventing diet-induced colonocyte genetic damage.
机译：膳食抗性淀粉（RS）作为高直链玉米淀粉（HAMS），可能通过大肠细菌RS发酵产生的短链脂肪酸（SCFA）丁酸盐来防止膳食蛋白引起的大鼠结肠细胞遗传损伤。丁酸酯利用率的提高可以改善结肠健康，饮食中高直链玉米玉米丁酸酯化淀粉（HAMSB）是实现这一目标的有效方法。在这项研究中，每组（每组8只）给大鼠喂食高含量（25％）的酪蛋白饮食蛋白和10％或20％的HAMSB和HAMS饮食。结肠细胞遗传损伤通过彗星试验测定，饲喂25％蛋白的大鼠比饲喂15％蛋白的大鼠高2倍（P <0.001）。相对于低RS高蛋白对照饮食，同时饲喂25％蛋白质以及HAMS或HAMSB可以显着降低遗传损害。 20％HAMSB饮食在对抗遗传损伤方面的功效是20％HAMS的两倍。与10％HAMS相比，喂食20％的大鼠和与10％HAMSB相比喂食20％的大鼠，大肠丁酸丁酸盐显着增加。相对于HAMS组，HAMSB组的水平明显更高。喂HAMS的大鼠肝门静脉SCFA较高，而喂HAMSB的大鼠肝门静脉SCFA最高。 HAMSB增加了盲肠的消化氨，并且与消化pH呈负相关。氨具有细胞毒性，较低的消化液pH值可能会降低其吸收，可能有助于降低遗传损害。 HAMSB将丁酸酯递送至大肠可通过预防饮食引起的结肠细胞遗传损伤来降低结直肠癌的风险。

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