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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Morel's laminar sclerosis showing apraxia of speech: distribution of cortical lesions in an autopsy case.
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Morel's laminar sclerosis showing apraxia of speech: distribution of cortical lesions in an autopsy case.

机译：莫雷尔的层状硬化症显示语言失语症：尸检病例的皮层病变分布。

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A 57-year old man with chronic alcoholism presented with apraxia of speech and disturbance of consciousness. He had a history of gastrectomy and had been drinking alcohol. The symptoms improved with administration of thiamine, but he later developed diarrhea and delirium, and died approximately 40 days after the onset. Autopsy findings were consistent with Wernicke's encephalopathy and pellagra encephalopathy. Furthermore, laminar cortical necrosis with vacuoles and astrocytosis was found in the second and third layers of the bilateral frontal cortices, suggesting Morel's laminar sclerosis. The lesions were mainly located in the bilateral primary motor cortices. Involvement of the lower part of the left primary motor cortex may be associated with apraxia of speech in our case.
机译：一名57岁的慢性酒精中毒患者，表现为语言失语和意识障碍。他有胃切除术史，曾经喝过酒。服用硫胺素后症状有所改善，但后来他出现腹泻和ir妄，并在发病后约40天死亡。尸检结果与韦尼克氏脑病和糙皮病脑病一致。此外，在双侧额叶皮层的第二层和第三层中发现了具有空泡和星形胶质细胞增多的层状皮质坏死，提示莫雷尔层状硬化症。病变主要位于双侧原发性运动皮层。在我们的病例中，左初级运动皮层下部的参与可能与语言失用有关。

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