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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >'Gliomatosis encephali' as a novel category of brain tumors by the first autopsy case report of gliomatosis cerebelli
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'Gliomatosis encephali' as a novel category of brain tumors by the first autopsy case report of gliomatosis cerebelli

机译：小脑胶质瘤病首例尸检报告“脑胶质瘤病”作为脑肿瘤的新类别

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摘要

Gliomatosis cerebri is a rare diffuse glioma that is neither mass-forming nor necrotic, and does not disrupt existing structures. Gliomatosis occurring in the cerebellum is known as gliomatosis cerebelli, and only three such cases examined by biopsy have been reported. Here we describe the first autopsy findings of a patient who was diagnosed as having gliomatosis in the cerebellum. Neuropathological examination identified the tumor cells as being positive for glial fibrillary acidic protein, vimentin and nestin, with atypical nuclei that were cashew-nut- or dishcloth-gourd-shaped. These tumor cells were dense in the right cerebellum, but also spread broadly throughout the brain including the left cerebrum and optic nerve. Mitotic figures were frequently seen in the cerebellum, brain stem and cerebrum. Scherer's secondary structures were evident not only in the cerebellum but also the cerebrum. No necrosis, microvascular proliferation or destruction of anatomical structures was detected in the whole brain. Differences in the origin of the tumors of the gliomatoses cerbri and cerebelli suggests these tumors are different types of brain tumors. Thus the findings support that the gliomatosis cerebelli is a novel type of brain tumor classification. Furthermore, by the similarities of the histological features among the tumors, it appears appropriate to establish a novel category of gliomatosis encephali which includes both gliomatosis cerebri and gliomatosis cerebelli.
机译：脑胶质瘤是一种罕见的弥散性神经胶质瘤，既不形成肿块也不坏死，也不破坏现有结构。小脑中发生的胶质瘤病被称为小脑胶质瘤，只有三例通过活检检查的病例。在这里，我们描述了被诊断为小脑胶质瘤病患者的首次尸检结果。神经病理学检查确定肿瘤细胞为神经胶质纤维酸性蛋白，波形蛋白和巢蛋白阳性，具有非典型核，呈腰果状或碗布状，葫芦状。这些肿瘤细胞在右小脑中密集，但也广泛分布在整个大脑中，包括左大脑和视神经。在小脑，脑干和大脑中经常见到有丝分裂图。 Scherer的二级结构不仅在小脑中而且在大脑中也很明显。在整个大脑中未发现坏死，微血管增生或解剖结构破坏。脑神经胶质瘤和小脑的肿瘤起源的差异表明这些肿瘤是脑瘤的不同类型。因此，发现支持小脑胶质瘤是一种新型的脑肿瘤分类。此外，通过肿瘤之间的组织学特征的相似性，似乎合适的是建立脑胶质瘤病的新型类别，其包括脑胶质瘤病和脑胶质瘤病。

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