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首页> 外文期刊>Neuron >Ambient illumination toggles a neuronal circuit switch in the retina and visual perception at cone threshold
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Ambient illumination toggles a neuronal circuit switch in the retina and visual perception at cone threshold

机译：环境照明可触发视网膜中的神经元电路开关，并在视锥细胞阈值处感知视觉

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摘要

Gradual changes in the sensory environment can lead to abrupt changes in brain computations and perception. However, mechanistic understanding of the mediating microcircuits is missing. By sliding through light levels from starlight to daylight, we identify retinal ganglion cell types in the mouse that abruptly and reversibly switch the weighting of center and surround interactions in their receptive field around cone threshold. Two-photon-targeted recordings and genetic and viral tracing experiments revealed that the circuit element responsible for the switch is a large inhibitory neuron that provides direct inhibition to ganglion cells. Our experiments suggest that weak excitatory input via electrical synapses together with the spiking threshold in inhibitory cells act as a switch. We also reveal a switch-like component in the spatial integration properties of human vision at cone threshold. This work demonstrates that circuits in the retina can quickly and reversibly switch between two distinct states, implementing distinct perceptual regimes at different light levels.
机译：感觉环境的逐渐变化会导致大脑计算和知觉的突然变化。然而，缺少对介导的微电路的机械理解。通过在从星光到日光的光线水平上滑动，我们确定了鼠标中视网膜神经节细胞的类型，这些类型突然和可逆地将中心和周围相互作用的权重切换到视锥阈附近。以两光子为目标的记录以及遗传和病毒示踪实验表明，负责转换的电路元件是一个大型抑制神经元，可直接抑制神经节细胞。我们的实验表明，经由电突触的弱兴奋性输入与抑制性细胞中的尖峰阈值一起起开关作用。我们还揭示了圆锥形阈值下人类视觉的空间整合特性中的类似开关的成分。这项工作表明，视网膜中的电路可以在两个不同的状态之间快速可逆地切换，从而在不同的光照水平下实现不同的感知状态。

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