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Increases in functional connectivity between prefrontal cortex and striatum during category learning

机译：在类别学习过程中前额叶皮层和纹状体之间的功能连接性增加

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Functional connectivity between the prefrontal cortex (PFC) and striatum (STR) is thought critical for cognition and has been linked to conditions like autism and schizophrenia. We recorded from multiple electrodes in PFC and STR while monkeys acquired new categories. Category learning was accompanied by an increase in beta band synchronization of LFPsbetween, but not within, the PFC and STR. Afterlearning, different pairs of PFC-STR electrodes showed stronger synchrony for one or the other category, suggesting category-specific functional circuits. This category-specific synchrony was also seen between PFC spikes and STR LFPs, but not the reverse, reflecting the direct monosynaptic connections from the PFC to STR. However, causal connectivity analyses suggested that the polysynaptic connections from STR to the PFC exerted a stronger overall influence. This supports models positing that the basal ganglia "train" the PFC. Category learning may depend on the formation of functional circuits between the PFC and STR.
机译：前额叶皮层（PFC）和纹状体（STR）之间的功能连接被认为对认知至关重要，并且已与自闭症和精神分裂症等疾病相关。我们从PFC和STR中的多个电极上记录下来，而猴子则获得了新的类别。类别学习伴随着PFC和STR之间（而非内部）的LFP的beta波段同步性增加。学习后，不同对的PFC-STR电极对一个或另一个类别显示出更强的同步性，表明类别特定的功能电路。在PFC尖峰和STR LFP之间也看到了特定于类别的同步，但没有相反，反映了从PFC到STR的直接单突触连接。但是，因果连通性分析表明，从STR到PFC的多突触连接具有更强的整体影响力。这支持了假定神经节“训练” PFC的模型。类别学习可能取决于PFC和STR之间功能电路的形成。

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