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首页> 外文期刊>Neuron >Connexin36 is essential for transmission of rod-mediated visual signals in the Mammalian retina.
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Connexin36 is essential for transmission of rod-mediated visual signals in the Mammalian retina.

机译：连接蛋白36对于哺乳动物视网膜中杆介导的视觉信号的传输至关重要。

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摘要

To examine the functions of electrical synapses in the transmission of signals from rod photoreceptors to ganglion cells, we generated connexin36 knockout mice. Reporter expression indicated that connexin36 was present in multiple retinal neurons including rod photoreceptors, cone bipolar cells, and AII amacrine cells. Disruption of electrical synapses between adjacent AIIs and between AIIs and ON cone bipolars was demonstrated by intracellular injection of Neurobiotin. In addition, extracellular recording in the knockout revealed the complete elimination of rod-mediated, on-center responses at the ganglion cell level. These data represent direct proof that electrical synapses are critical for the propagation of rod signals across the mammalian retina, and they demonstrate the existence of multiple rod pathways, each of which is dependent on electrical synapses.
机译：为了检查电突触在棒状光感受器向神经节细胞信号传递中的功能，我们产生了连接蛋白36基因敲除小鼠。记者的表达表明，连接蛋白36存在于多个视网膜神经元中，包括视杆感光细胞，视锥双极细胞和AII无长突细胞。通过细胞内注射神经生物素证明了相邻的AII之间以及AII与ON锥双极之间的电突触破坏。此外，基因敲除的细胞外记录显示在神经节细胞水平上完全消除了杆介导的中心响应。这些数据直接证明了电突触对于杆信号在哺乳动物视网膜中的传播至关重要，并且它们表明存在多个杆通路，每个通路均依赖于电突触。

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