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Study of low-density lipoprotein oxidizability indexes to measure theantioxidant activity of dietary polyphenols

机译：低密度脂蛋白氧化指标测定膳食多酚抗氧化活性的研究

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Oxidation of low-density lipoprotein (LDL) may be important in the pathogenesis of atherosclerosis. Recent studies have reported that specific polyphenols play a role as antioxidants inhibiting lipid peroxidation, LDL oxidation and scavenging oxygen radicals. To investigate the mechanism by which dietary antioxidants may reduce the risk of atherosclerosis by inhibiting oxidative damage of lipoproteins, low-density lipoprotein oxidizability indexes were studied to measure the antioxidant activity of dietary polyphenols and a modification in the CLT50 parameter was proposed. This parameter measure the concentration of antioxidant that increase the Lag time to 50% greater than that of the control, and the proposed modification eliminate the effects of the LDL status in the oxidation induced with Cu2+. The lower the CLT50, the higher antioxidant activity in the inhibition of LDL oxidation. Polyphenols with different structures such as condensed tannins (tannin acid), flavonols (catechin, quercetin, rutin), cinnamic acids (caffeic and ferulic acid), stilbenes (resveratrol), benzoic acids (gallic acid), anthocyanidins (malvidin); a synthetic phenol (3-tert-butyl-4-hydroxyanisole, BHA) and two vitamins (ascorbic acid vitamin C- and DL-alpha-tocopherol -vitamin E-) were studied. All antioxidants tested showed dose-dependent inhibition of LDL oxidation. In general, it was suggested that dietary polyphenols are better antioxidants than other common antioxidants, such as vitamin C and E. An adequate study of the low-density lipoprotein oxidizability indexes could determine the serum antioxidant status within different subjects, and/or evaluate the antioxidant efficiency of different antioxidants in the inhibition of human LDL oxidation.
机译：低密度脂蛋白（LDL）的氧化可能在动脉粥样硬化的发病机制中很重要。最近的研究报道，特定的多酚起着抗氧化剂的作用，可抑制脂质过氧化，LDL氧化和清除氧自由基。为了研究膳食抗氧化剂通过抑制脂蛋白的氧化损伤而降低动脉粥样硬化风险的机制，研究了低密度脂蛋白的氧化性指标以测定膳食多酚的抗氧化活性，并提出了CLT50参数的修改方法。该参数测量的抗氧化剂浓度可将滞后时间延长至比对照的滞后时间长50％，并且拟议的修饰消除了LDL状态对Cu2 +诱导的氧化的影响。 CLT50越低，抑制LDL氧化的抗氧化剂活性就越高。具有不同结构的多酚，例如缩合的丹宁酸（单宁酸），黄酮醇（儿茶素，槲皮素，芦丁），肉桂酸（咖啡酸和阿魏酸），丁苯醚（白藜芦醇），苯甲酸（没食子酸），花青素（麦维京）;研究了合成苯酚（3-叔丁基-4-羟基茴香醚，BHA）和两种维生素（抗坏血酸维生素C和DL-α-生育酚-维生素E-）。所有测试的抗氧化剂均显示出剂量依赖性的LDL氧化抑制作用。一般而言，有人建议饮食中的多酚是比其他常见的抗氧化剂（例如维生素C和E）更好的抗氧化剂。对低密度脂蛋白氧化性指数的充分研究可以确定不同受试者的血清抗氧化剂状态，和/或评估抗氧化剂的功效不同抗氧化剂在抑制人类LDL氧化方面的作用。

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