• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell metabolism >Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN
【24h】

Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN

机译：弓形NPY通过PVN中酪氨酸羟化酶神经元的中继来控制交感神经输出和BAT功能

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the control of sympathetic outflow and brown adipose tissue (BAT) function. Mechanistically, a key change induced by Arc NPY signaling is a marked Y1 receptor-mediated reduction in tyrosine hydroxylase (TH) expression in the hypothalamic paraventricular nucleus (PVN), which is also associated with a reduction in TH expression in the locus coeruleus (LC) and other regions in the brainstem. Consistent with this, Arc NPY signaling decreased sympathetically innervated BAT thermogenesis, involving the downregulation of uncoupling protein 1 (UCP1) expression in BAT. Taken together, these data reveal a powerful Arc-NPY-regulated neuronal circuit that controls BAT thermogenesis and sympathetic output via TH neurons.
机译：Neuropepetide Y（NPY）以其对食物摄入的强大刺激作用以及对减少能量消耗的作用而闻名。但是，涉及的途径和背后的调控机制尚不十分清楚。在这里，我们证明了源自弓形核（Arc）的NPY对于控制交感神经流出和褐色脂肪组织（BAT）功能至关重要。从机理上讲，由弧线NPY信号引起的关键变化是下丘脑室旁核（PVN）中酪氨酸羟化酶（TH）表达的Y1受体介导的显着减少，这也与蓝斑脑（LC）中TH表达的减少有关）和脑干的其他区域。与此相一致，Arc NPY信号传导减少了交感神经支配的BAT生热作用，涉及下调BAT中解偶联蛋白1（UCP1）的表达。综上所述，这些数据揭示了一个强大的Arc-NPY调节神经元回路，该回路控制BAT生热和TH神经元产生的交感神经输出。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号