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首页> 外文期刊>Laboratory Animal Science >Sustained estrogenization is insufficient to support long-term experimentally induced genital Trichomonas vaginalis infection in BALB/c mice.
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Sustained estrogenization is insufficient to support long-term experimentally induced genital Trichomonas vaginalis infection in BALB/c mice.

机译：持续的雌激素作用不足以支持BALB / c小鼠的长期实验性生殖道阴道滴虫感染。

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摘要

In order to test whether sustained oestrogenization could support long-term experimentally induced genital Trichomonas vaginalis infection in mice, 40 BALB/c AnNCr mice were given 17 mug of 17beta-oestradiol in subcutaneous implants, and 20 were inoculated intravaginally with 8.0 X 105 ATCC no. 30488 Trichomonas vaginalis on days 2 and 3 postoestrogenization; the other 20 were injected with saline solution as controls. Five mice from each group were killed and necropsied at weeks 2, 4 and 6, by which time none remained infected. All mice remained clinically normal throughout, and histological changes were slight, and similar in both groups. It is concluded that the sustained release of 17beta-oestradiol does not prolong the course of murine genitalTrichomonas vaginalis infection beyond the time achievable by other methods.
机译：为了测试持续的雌激素是否可以支持小鼠的长期实验性生殖道阴道毛滴虫感染，对40例BALB / c AnNCr小鼠皮下植入了17杯17beta-雌二醇，并用8.0 X 105 ATCC阴道内接种了20只。 。雌激素后第2天和第3天产生阴道毛滴虫30488;其余20只注射生理盐水作为对照。在第2、4和6周，将每组的五只小鼠处死并进行尸检，到那时都没有感染。在整个过程中，所有小鼠均保持临床正常，并且组织学变化很小，两组相似。结论是，17β-雌二醇的持续释放不会延长鼠生殖器阴道滴虫的病程超过其他方法可达到的时间。

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