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首页> 外文期刊>Cell biology international. >Involvement of peroxiredoxin IV in the 16-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells
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Involvement of peroxiredoxin IV in the 16-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells

机译：Peroxiredoxin IV与16-羟基雌酮诱导的人MCF-7乳腺癌细胞增殖的关系

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摘要

A variety of investigations on peroxiredoxins (Prxs) in different types of cancer have been carried out, but the estrogen-related function of Prxs in breast cancer has not yet been studied. In order to study the involvement of Prxs in the growth of breast cancer cells by estrogen, we evaluated the effect of mitogenic estrogen metabolites on the expression of Prx isoforms (I to VI) in MCF-7 cells and found that the transcript/protein expression of Prx IV was significantly induced by 16-hydroxyestrone (OHE1) under both serum-free and serum conditions. In addition, treatment with Prx IV-specific siRNA significantly inhibited the 16-OHE1-induced proliferation of MCF-7 cells. These results suggested that Prx IV involved in the 16-OHE1-induced proliferation of MCF-7 cells has a proliferative effect and may be related to cancer development or progression.
机译：已经对各种类型的癌症中的过氧化物酶（Prxs）进行了各种研究，但是尚未研究Prxs在乳腺癌中与雌激素相关的功能。为了研究雌激素对Prxs参与乳腺癌细胞生长的影响，我们评估了有丝分裂雌激素代谢产物对MCF-7细胞Prx亚型（I至VI）表达的影响，并发现了转录本/蛋白质表达在无血清和血清条件下，16-羟基雌酮（OHE1）均可显着诱导Prx IV的表达。此外，用Prx IV特异性siRNA处理可显着抑制16-OHE1诱导的MCF-7细胞增殖。这些结果表明，参与16-OHE1诱导的MCF-7细胞增殖的Prx IV具有增殖作用，并且可能与癌症的发生或发展有关。

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