Effect of exercise on hepatic gene expression in rats: a microarray analysis

Aoi W; Ichiishi E; Sakamoto N; Tsujimoto A; Tokuda H; Yoshikawa T

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Effect of exercise on hepatic gene expression in rats: a microarray analysis

机译：运动对大鼠肝基因表达的影响：微阵列分析

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Exercise has various beneficial effects on liver function, enhancing both nutrient metabolism and antioxidant capacity. To explore the molecular mechanisms underlying these changes, we used a high-density cDNA microarray containing probe sets for 2,845 genes to analyze changes of gene transcription in the livers of rats after 4 weeks of running exercise. In comparison with sedentary animals, 105 genes were up-regulated and 86 genes were down-regulated, including genes with unknown functions. In addition, we detected an increase of p38 mitogen-activated protein kinase and protein and of the protein for signal transducer and activator of transcription 3 (stat3), corresponding to the increase of these mRNAs shown by microarray analysis. These results indicate that long-term exercise can alter liver function via changes of gene expression, especially the genes encoding signal transduction proteins such as p38 and stat3. (C) 2004 Elsevier Inc. All rights reserved.

机译：运动对肝功能有多种有益作用，既增强营养代谢又增强抗氧化能力。为了探索这些变化的潜在分子机制，我们使用了包含2845个基因的探针集的高密度cDNA微阵列，分析了跑步4周后大鼠肝脏中基因转录的变化。与久坐的动物相比，上调了105个基因，下调了86个基因，包括功能未知的基因。此外，我们检测到p38丝裂原激活的蛋白激酶和蛋白以及信号转导和转录激活因子3（stat3）的蛋白增加，与微阵列分析显示的这些mRNA的增加相对应。这些结果表明，长期锻炼可以通过基因表达的改变来改变肝功能，尤其是编码信号转导蛋白如p38和stat3的基因。（C）2004 Elsevier Inc.保留所有权利。

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《Life sciences》 |2004年第26期|共12页
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Aoi W; Ichiishi E; Sakamoto N; Tsujimoto A; Tokuda H; Yoshikawa T;
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正文语种 eng
中图分类生命的起源;
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gene expression; liver; exercise training; microarray; p38; stat3; GROWTH-HORMONE; TISSUE-DAMAGE; LIVER; ENDURANCE; METABOLISM; INSULIN; ACTIVATION; SYNTHASE; GLUCOSE; SYSTEM;

机译：基因表达;肝脏;运动训练;微阵列;p38;stat3;生长激素;组织损伤;肝脏;耐力;代谢;胰岛素;活化;合酶;葡萄糖;系统;

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1. Effect of exercise on hepatic gene expression in rats: a microarray analysis [J] . Aoi W, Ichiishi E, Sakamoto N, Life sciences . 2004,第26期

机译：运动对大鼠肝基因表达的影响：微阵列分析
2. Prevention of hyperglycemia in Zucker diabetic fatty rats by exercise training: effects on gene expression in insulin-sensitive tissues determined by high-density oligonucleotide microarray analysis. [J] . Colombo M, Gregersen S, Kruhoeffer M, Metabolism: Clinical and Experimental . 2005,第12期

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3. Melatonin or ramelteon therapy differentially affects hepatic gene expression profiles after haemorrhagic shock in rat - A microarray analysis [J] . Kleber Astrid, Ruf Christian G., Wolf Alexander, Experimental & Molecular Pathology . 2015,第2期

机译：褪黑素或雷梅替尼疗法对大鼠失血性休克后肝基因表达谱的影响不同-芯片分析
4. Phenotype prediction by integrative network analysis of SNP and gene expression microarrays [C] . Chang Hsun-Hsien, McGeachie Michael 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2011

机译：通过SNP和基因表达微阵列的综合网络分析预测表型
5. Microarray analysis of hepatic gene expression during the development of diet-induced obesity. [D] . Patel, Vira. 2003

机译：饮食诱导的肥胖发生过程中肝基因表达的微阵列分析。
6. Effect of leucine uptake on hepatic and skeletal muscle gene expression in rats: a microarray analysis [O] . Wookwang Cheon 2015

机译：亮氨酸摄取对大鼠肝和骨骼肌基因表达的影响：微阵列分析
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Effect of exercise on hepatic gene expression in rats: a microarray analysis

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