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首页> 外文期刊>Life sciences >Changes of cerebral blood oxygenation and optical pathlength during activation and deactivation in the prefrontal cortex measured by time-resolved near infrared spectroscopy.
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Changes of cerebral blood oxygenation and optical pathlength during activation and deactivation in the prefrontal cortex measured by time-resolved near infrared spectroscopy.

机译：用时间分辨近红外光谱法测定前额叶皮层激活和失活期间脑血氧合和光程的变化。

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摘要

To determine the alterations in optical characteristics and cerebral blood oxygenation (CBO) during activation and deactivation, we evaluated the changes in mean optical pathlength (MOP) and CBO induced by a verbal fluency task (VFT) and driving simulation in the right and left prefrontal cortex (PFC), employing a newly developed time-resolved near infrared spectroscopy, which allows quantitative measurements of the evoked-CBO changes by determining the MOP with a sampling time of 1 s. The results demonstrated differences in MOP in the foreheads with the subjects and wavelength; however, there was no significant difference between the right and left foreheads (p > 0.05). Also, both the VFT and driving simulation task did not affect the MOP significantly as compared to that before the tasks (p > 0.05). In the bilateral PFCs, the VFT caused increases of oxyhemoglobin and total hemoglobin associated with a decrease of deoxyhemoglobin, while the driving simulation task caused decreases of oxyhemoglobin and total hemoglobin associated with an increase of deoxyhemoglobin; there were no significant differences in evoked-CBO changes between the right and left PFC. The present results will be useful for quantitative measurement of hemodynamic changes during activation and deactivation in the adults by near infrared spectroscopy.
机译：为了确定激活和去激活过程中光学特性和脑血氧合（CBO）的变化，我们评估了语言流利度任务（VFT）和左右前额叶驾驶模拟所引起的平均光程长度（MOP）和CBO的变化皮质（PFC），采用新开发的时间分辨近红外光谱技术，通过以1 s的采样时间确定MOP，可以定量测量诱发的CBO变化。结果表明，额头上的MOP随受试者和波长的不同而不同。然而，左右额头之间没有显着差异（p> 0.05）。此外，与执行任务之前相比，VFT和驾驶模拟任务均未对MOP产生显着影响（p> 0.05）。在双侧PFC中，VFT引起氧合血红蛋白和总血红蛋白的增加与脱氧血红蛋白的减少有关，而驾驶模拟任务导致氧合血红蛋白和总血红蛋白的减少与脱氧血红蛋白的增加有关;左右PFC之间的诱发CBO变化无明显差异。本研究结果对于通过近红外光谱在成年人激活和失活过程中的血液动力学变化的定量测量将是有用的。

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