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首页> 外文期刊>Life sciences >Differences in hypothyroidism between lithium-free and -treated patients with bipolar disorders.
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Differences in hypothyroidism between lithium-free and -treated patients with bipolar disorders.

机译：无锂患者和接受治疗的躁郁症患者甲状腺功能减退的差异。

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The majority of the previous studies of thyroid abnormalities in bipolar patients was conducted in populations containing various proportions of lithium-treated subjects. In the present study, we sought to determine whether there exist differences in hypothyroid profile between lithium-free and -treated bipolar patients. Bipolar patients never treated with lithium and carbamazepine (n=78) and those currently in lithium therapy (n=53) were included in this study. Serum concentrations of total thyroxine (T(4)), total triiodothyronine (T(3)), and thyroid-stimulating hormone (TSH) were compared between lithium-free and -treated patients. The rate of hypothyroidism in lithium-free patients was significantly lower than those treated with lithium (6.3%-10.8% vs. 28.0%-32.1%). Significant changes in the three thyroid indices indicative of hypothyroidism were consistently associated with longer illness duration in lithium-free manic patients, but with greater severity of mania and more mood episodes in their lithium-treated counterparts. In lithium-free depressed patients, more episodes were associated with lower T(4) levels; whereas in their lithium-treated counterparts, longer illness duration was associated with higher TSH levels and females with lower T(3) levels. These results suggest that bipolar patients with and without lithium exposure differ in prevalence and association of hypothyroidism and may have different response to thyroid hormone therapy.
机译：以往双相情感障碍患者甲状腺异常的大多数研究都是在包含不同比例的锂治疗对象的人群中进行的。在本研究中，我们试图确定在无锂患者和接受治疗的双相情感障碍患者之间甲状腺功能减退方面是否存在差异。从未接受过锂和卡马西平治疗的双相型患者（n = 78）和目前接受锂治疗的患者（n = 53）都包括在本研究中。比较了无锂患者和接受治疗的患者的血清总甲状腺素（T（4）），总三碘甲状腺素（T（3））和促甲状腺激素（TSH）的浓度。无锂患者的甲状腺功能减退率明显低于用锂治疗的患者（6.3％-10.8％对28.0％-32.1％）。指示甲状腺功能减退症的三个甲状腺指数的显着变化与无锂躁狂患者的病程更长有关，但与锂治疗的躁狂患者相比，躁狂的严重程度更高，情绪发作更多。在无锂抑郁症患者中，更多的发作与较低的T（4）水平相关。而在接受锂治疗的同行中，病程越长，TSH水平越高，女性T（3）水平越低。这些结果表明，有和没有锂暴露的双相情感障碍患者的甲状腺功能减退的患病率和关联不同，并且对甲状腺激素治疗的反应可能不同。

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