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首页> 外文期刊>Life sciences >Melatonin decreases bone marrow and lymphatic toxicity of adriamycin in mice bearing TLX5 lymphoma.
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Melatonin decreases bone marrow and lymphatic toxicity of adriamycin in mice bearing TLX5 lymphoma.

机译：褪黑激素可降低阿霉素对患有TLX5淋巴瘤的小鼠的骨髓和淋巴毒性。

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摘要

When CBA male mice bearing TLX5 lymphoma were treated in the evening with a single i.v. dose of adriamycin (20-40 mg/Kg), the administration of a single pharmacological dose of melatonin (10 mg/kg s.c.) 1 hr earlier reduced the acute mortality from 10/24 to 2/24. The increase in survival time caused by adriamycin over drug untreated controls was not reduced by melatonin. The administration of melatonin alone did not cause any antitumor or evident toxic effect. Melatonin also attenuated the reduction caused by adriamycin in the number of bone marrow GM-CFU, and of CD3+, CD4+ and CD8+ splenic T-lymphocyte subsets. Reduced and total glutathione levels were decreased in the bone marrow and in the liver cells of the animals treated with adriamycin, and were significantly restored by melatonin. Moreover, lipid peroxidation by adriamycin was reduced by melatonin, as indicated by malondialdehyde measurement in the liver of the treated animals. These data indicate that the protective effects of melatonin against the host toxicity of the prooxidant antitumor drug, adriamycin, might be attributed at least partially to its antioxidant properties. These findings appear of interest in relation to the physiological rhythmic levels of endogenous melatonin and to the chronotoxicology of anthracyclines.
机译：当CBA携带TLX5淋巴瘤的雄性小鼠在晚上用一次静脉注射治疗。剂量的阿霉素（20-40 mg / Kg），单次药理剂量的褪黑激素（10 mg / kg s.c.）提前1小时将急性死亡率从10/24降低到2/24。褪黑激素并没有降低阿霉素引起的存活时间相对于未治疗药物对照组的增加。单独服用褪黑激素不会引起任何抗肿瘤或明显的毒性作用。褪黑激素还减弱了由阿霉素引起的骨髓GM-CFU以及CD3 +，CD4 +和CD8 +脾T淋巴细胞亚群数量的减少。在用阿霉素治疗的动物的骨髓和肝细胞中，谷胱甘肽的降低和总谷胱甘肽水平降低，并且褪黑激素可以使谷胱甘肽显着恢复。此外，褪黑激素降低了阿霉素的脂质过氧化作用，如治疗动物肝脏中丙二醛的测定所表明的。这些数据表明褪黑激素对抗氧化剂抗肿瘤药阿霉素的宿主毒性的保护作用至少可以部分归因于其抗氧化特性。这些发现与内源性褪黑激素的生理节律水平和蒽环类抗生素的时间毒性有关。

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