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Effect of excitotoxic lesions of the neonatal ventral hippocampus on the immobility response in rats.

机译:新生腹侧海马兴奋性损伤对大鼠运动反应的影响。

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摘要

Rats with neonatal ventral hippocampal (nVH) lesions show postpubertal hypersensitivity to dopamine agonists, which may be reversed by neuroleptic treatment. In addition, the immobility response (IR) may be regulated by dopaminergic activity. We investigated the influence of the IR caused by clamping the neck of rats that had received bilateral ibotenic acid lesions of the ventral hippocampus at postnatal day 7 (PD7). At both ages, prepubertal (PD35) and postpubertal (PD56), the duration of the IR was significantly increased in animals with lesions when compared to controls. These findings indicate that nVH damage results in behavioral changes, such as enhancement of the IR, related to mesolimbic dopaminergic transmission.
机译:患有新生腹侧海马(nVH)损伤的大鼠表现出青春期后对多巴胺激动剂的超敏反应,这可能会通过精神抑制药逆转。另外,固定反应(IR)可以通过多巴胺能活性来调节。我们调查了在出生后第7天(PD7)夹住腹侧海马双侧ibotenic acid病变的大鼠的脖子引起的IR的影响。在两个年龄段,青春期前(PD35)和青春期后(PD56),与对照组相比,有病变的动物的IR持续时间显着增加。这些发现表明,nVH损伤导致与中脑边缘多巴胺能传递有关的行为改变,例如IR的增强。

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