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首页> 外文期刊>Life sciences >The effects of zenarestat, an aldose reductase inhibitor, on minimal F-wave latency and nerve blood flow in streptozotocin-induced diabetic rats.
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The effects of zenarestat, an aldose reductase inhibitor, on minimal F-wave latency and nerve blood flow in streptozotocin-induced diabetic rats.

机译：zenarestat（一种醛糖还原酶抑制剂）对链脲佐菌素诱发的糖尿病大鼠的最小F波潜伏期和神经血流的影响。

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摘要

The effects of zenarestat, 3-(4-bromo-2-fluorobenzyl)-7-chloro-3,4-dihydro-2,4-dioxo-1(2H)-quinazolineacetic acid, an aldose reductase inhibitor (ARI), on F-wave conduction abnormalities, nerve blood flow (NBF) reduction and sorbitol accumulation were studied in streptozotocin-induced diabetic rats. Two weeks after the induction of diabetes, zenarestat was given once a day for two weeks. In diabetic control rats, marked accumulation of sorbitol, reduction of NBF and prolongation of minimal F-wave latency (FWL) were observed as compared to normal rats. Zenarestat, at a dose of 32 mg/kg, inhibited sorbitol concentration to nearly the normal rat level and significantly improved not only NBF but also minimal FWL. At a dose of 3.2 mg/kg, sorbitol accumulation was inhibited by approximately 40% and there was a tendency to increase in NBF; however, minimal FWL was not improved at all. These data suggest that a highly inhibition of the nerve sorbitol accumulation is requisite for the treatment of diabetic peripheral neuropathy.
机译：zenarestat，醛糖还原酶抑制剂（ARI）对3-（4-溴-2-氟苄基）-7-氯-3,4-二氢-2,4-二氧代-1（2H）-喹唑啉乙酸的影响在链脲佐菌素诱导的糖尿病大鼠中研究了F波传导异常，神经血流量（NBF）减少和山梨糖醇积累。诱发糖尿病两周后，每天一次给予zenarestat，持续两周。与正常大鼠相比，在糖尿病对照大鼠中，观察到山梨糖醇显着积累，NBF降低和最小F波潜伏期（FWL）延长。 Zenarestat的剂量为32 mg / kg，可将山梨醇的浓度抑制到接近正常大鼠水平，不仅显着改善了NBF，而且显着改善了FWL。在3.2 mg / kg的剂量下，山梨糖醇的积累被抑制约40％，并且NBF有增加的趋势。但是，最小的FWL根本没有改善。这些数据表明，高度抑制神经性山梨糖醇蓄积是治疗糖尿病周围神经病的必要条件。

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