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Analysis of immunomodulating cytokine mRNAs in the mouse induced by mushroom polysaccharides.

机译:蘑菇多糖诱导的小鼠免疫调节细胞因子mRNA分析。

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摘要

The immunomodulating action of two mushroom antitumor polysaccharides, polysaccharide-protein complex (PSPC) and lentinan, was elucidated through analysing the expression profile of cytokines during a time course (0 h to 48 h) after their administration. Among the 5 cytokine genes, the induction of a marked increase in the mRNA levels of IL-1alpha, IL-1beta, TNF-alpha, IFN-gamma and M-CSF by PSPC and lentinan was observed in the peritoneal exudate cells and splenocytes. However, the time point of their increased production was different after PSPC and lentinan administration.
机译:通过分析两种细胞因子在施用后一段时间(0 h至48 h)的表达情况,阐明了两种蘑菇抗肿瘤多糖(PSPC)和香菇多糖的免疫调节作用。在5种细胞因子基因中,在腹膜渗出细胞和脾细胞中观察到PSPC和香菇多糖诱导IL-1α,IL-1β,TNF-α,IFN-γ和M-CSF的mRNA水平显着增加。但是,PSPC和香菇多糖施用后,它们增加产量的时间点有所不同。

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