Calcium mobilization evoked by amyloid beta-protein involves inositol 1,4,5-triphosphate production in human platelets.

Ishikawa H; Ozawa H; Saito T; Takahata N; Takemura H

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Calcium mobilization evoked by amyloid beta-protein involves inositol 1,4,5-triphosphate production in human platelets.

机译：淀粉样β蛋白诱发的钙动员涉及人血小板中肌醇1,4,5-三磷酸的产生。

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We examined the effects of amyloid beta-protein (A beta) on Ca2+ mobilization in human platelets. The addition of A beta fragments 25-35 (A beta 25-35) gradually increased the cytoplasmic free Ca2+ concentration ([Ca2+]i). After the maximum response, [Ca2+]i decreased and then reached a sustained, higher level of [Ca2+]i. Similar effects were also observed with A beta 1-40, whereas 1-28 , 12-28 and 31-35 did not affect the Ca2+ response. In the absence of extracellular Ca2+, A beta 25-35 caused a transient increase in [Ca2+]i, which returned to the resting level. U73122, a phospholipase C inhibitor, completely abolished Ca2+ mobilization induced by thrombin and A beta 25-35. Furthermore, A beta enhanced the production of inositol 1,4,5-trisphosphate (IP3) in platelets. These findings suggest that Ca2+ mobilization induced by A beta 25-35 is due to phospholipase C activation and IP3 production.

机译：我们检查了淀粉样蛋白β蛋白（A beta）对人类血小板中Ca2 +动员的影响。 A beta片段25-35（A beta 25-35）的添加逐渐增加了细胞质中游离Ca2 +的浓度（[Ca2 +] i）。达到最大响应后，[Ca2 +] i降低，然后达到持续较高的[Ca2 +] i水平。使用A beta 1-40也观察到类似的效果，而1-28、12-28和31-35不会影响Ca2 +反应。在不存在细胞外Ca2 +的情况下，A beta 25-35导致[Ca2 +] i瞬时增加，并恢复到静止水平。磷脂酶C抑制剂U73122完全消除了凝血酶和A beta 25-35诱导的Ca2 +动员。此外，β增加了血小板中肌醇1,4,5-三磷酸（IP3）的产生。这些发现表明，A beta 25-35诱导的Ca2 +动员是由于磷脂酶C活化和IP3产生。

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《Life sciences》 |1998年第8期|共9页
作者
Ishikawa H; Ozawa H; Saito T; Takahata N; Takemura H;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Amyloid beta-Protein; Blood Platelets; Calcium; Inositol 1; 4; 5-Trisphosphate; 淀粉样β蛋白; 血小板; 钙; 肌醇1; 4; 5-三磷酸;

机译：Amyloid beta-Protein;Blood Platelets;Calcium;Inositol 1;4;5-Trisphosphate;淀粉样β蛋白;血小板;钙;肌醇1;4;5-三磷酸;

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1. Calcium mobilization evoked by amyloid beta-protein involves inositol 1,4,5-triphosphate production in human platelets. [J] . Ishikawa H, Ozawa H, Saito T, Life sciences . 1998,第8期

机译：淀粉样β蛋白诱发的钙动员涉及人血小板中肌醇1,4,5-三磷酸的产生。
2. Stereospecific mobilization of intracellular Ca2+ by inositol 1,4,5-triphosphate. Comparison with inositol 1,4,5-trisphosphorothioate and inositol 1,3,4-trisphosphate [J] . A M Cooke, B V L Potter, J Strupish, The biochemical journal . 1988,第3期

机译：肌醇1,4,5-三磷酸肌醇对细胞内Ca2 +的立体定向动员。与肌醇1,4,5-三硫代磷酸酯和肌醇1,3,4-三磷酸酯的比较
3. Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets. [J] . Rosado JA, Sage SO The Biochemical Journal . 2001,第Pta1期

机译：II型肌醇1,4,5-三磷酸受体与人类血小板中人类瞬态受体电位（hTrp1）通道之间的分泌样偶联激活存储介导的钙进入。
4. A model of inositol 1,4,5-trisphosphate and calcium dynamics in single cells following metabotropic receptor activation [C] . Greg Lemon, William G. Gibson, Max R. Bennett Computational neuroscience meeting . 2003

机译：代谢受体激活后单细胞肌醇1,4,5-三磷酸盐和钙动力学模型
5. The inositol 1,4,5-triphosphate signal transduction pathway and magnesium ion mediate lipopolysaccharide-induced exocytosis in the hemocyte of the horseshoe crab, Limulus polyphemus (L.). [D] . Solon, Eric George. 1996

机译：肌醇1,4,5-三磷酸信号传导途径和镁离子介导脂多糖诱导的o马血phe（L.）的血细胞中的胞吐作用。
6. Activation of the Inositol (1,4,5)-Triphosphate Calcium Gate Receptor Is Required for HIV-1 Gag Release [O] . Lorna S. Ehrlich, Gisselle N. Medina, Mahfuz B. Khan, 2000

机译：HIV-1释放释放需要激活肌醇（1,4,5）-三磷酸钙门控受体
7. Stereospecific mobilization of intracellular Ca2+ by inositol 1,4,5-triphosphate. Comparison with inositol 1,4,5-trisphosphorothioate and inositol 1,3,4-trisphosphate. [O] . Strupish, J, Cooke, A M, Potter, B V, 1988

机译：肌醇1,4,5-三磷酸肌醇对细胞内Ca2 +的立体定向动员。与肌醇1,4,5-三硫代磷酸酯和肌醇1,3,4-三磷酸酯的比较。
8. Brain Damage from Soman-Induced Seizures Is Greatly Exacerbated by Dimethyl sulfoxide (DMSO): Modest Neuroprotection by 2-Aminoethyl diphenylborinate (2- APB), a Transient Receptor Potential Channel Inhibitor and Inositol 1,4,5-triphosphate Receptor Antagonist [R] . Ballough, G. P., Kan, R. K., Nicholson, J. D., 2008

机译：二甲基亚砜（DmsO）大大加剧梭曼诱发癫痫发作引起的脑损伤：2-氨基乙基二苯基硼酸盐（2- apB），一种瞬时受体电位通道抑制剂和肌醇1,4,5-三磷酸受体拮抗剂的适度神经保护作用

Calcium mobilization evoked by amyloid beta-protein involves inositol 1,4,5-triphosphate production in human platelets.

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