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Nicotinic receptor and tobacco-related cancer.

机译：烟碱受体和与烟草有关的癌症。

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摘要

Currently, tobacco smoking causes approximately 5-6 million deaths per year including more than 35% of all cancer deaths. Nicotine, the addictive constituent of tobacco, and its derived carcinogenic nitrosamines, contribute to cancer promotion and progression through the activation of nicotinic acetylcholine receptors (nAChR). Although the role of nicotine in cancerogenesis is still discussed controversially, it has been recently shown that nicotine induces DNA damages, via induction of oxidative stress, in bronchial epithelial cells. Moreover, nicotine is able to induce muscle sarcomas in A/J mice. In this mini-review we highlight the role of nAChR and nicotine in all cancer phases (induction, promotion and progression). Relevant new findings quoted in literature and some new experiments of our laboratory were reported and discussed.
机译：目前，吸烟每年导致大约5-6百万人死亡，包括所有癌症死亡的35％以上。烟草成瘾性成分尼古丁及其衍生的致癌亚硝胺通过激活烟碱乙酰胆碱受体（nAChR）促进癌症的发展和进展。尽管尼古丁在癌症发生中的作用仍存在争议，但最近已显示尼古丁通过诱导氧化应激在支气管上皮细胞中诱导DNA损伤。此外，尼古丁能够在A / J小鼠中诱发肌肉肉瘤。在本微型综述中，我们重点介绍了nAChR和尼古丁在所有癌症阶段（诱导，促进和进展）中的作用。报告并讨论了文献中引用的相关新发现和我们实验室的一些新实验。

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