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首页> 外文期刊>Life sciences >The effect of azelastin hydrochloride on pruritus and leukotriene B4 in hemodialysis patients.
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The effect of azelastin hydrochloride on pruritus and leukotriene B4 in hemodialysis patients.

机译：盐酸氮卓斯汀对血液透析患者瘙痒和白三烯B4的影响。

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Pruritus is a very common complication in chronic hemodialysis (HD) patients, however the exact mechanism for this affliction is still not known. Anti-histaminics usually failed to alleviate uremic pruritus. In others, an anti-allergic drug, which inhibits the release of chemical mediators, such as leukotrienes or histamine from mast cells, was reported to be effective. We evaluated the values of leukotriene B4 and interleukin 6 in HD patients with pruritus and the effect of an anti-allergic drug on these factors. Leukotriene B4, interleukin-6, C3a, C5a, the number of eosinophil and IgE at 0, 15 and 180 minutes after the start of regular HD in 11 HD patients suffering from pruritus and as well as in 11 HD patients without pruritus were examined. These HD patients in both groups showed significantly higher (p < 0.001) values of leukotriene B4 and C3a compared to healthy non-HD subjects. There was no difference in the leukotriene B4, interleukin-6, IgE, C3a and C5a levels between the patients with and without pruritus. Two mg/day of azelastin hydrochloride, an anti-allergic drug was orally given to the pruritus group for 3 weeks. In 5 of 11 patients, the pruritus symptoms disappeared, while in 4 of 11 they improved. Independent of the effect of the drug on pruritus, leukotriene B4 levels significantly decreased compared with those before the administration of this drug in the pruritus group (p < 0.01). Interleukin 6, C3a, C5a and the number of eosinophils demonstrated no significant change. In conclusion, although azelastin hydrochloride was effective in treating pruritus and also suppressed leukotriene B4 levels in hemodialysis patients, the high leukotriene B4 activity itself did not seem to be related to the development of pruritus in these patients.
机译：瘙痒是慢性血液透析（HD）患者的一种非常常见的并发症，但是这种病的确切机制仍然未知。抗组胺药通常不能缓解尿毒症瘙痒症。在其他文献中，据报道，一种抗过敏药可有效抑制肥大细胞中白三烯或组胺等化学介质的释放。我们评估了白内障患者HD中白三烯B4和白介素6的值，以及抗过敏药对这些因素的影响。在11例患有瘙痒症的HD患者和11例无瘙痒症的HD患者中，检查了白细胞三烯B4，白细胞介素6，C3a，C5a，嗜酸性粒细胞和IgE的数目，在常规HD开始后0、15和180分钟开始。与健康的非HD患者相比，两组中的HD患者的白三烯B4和C3a值均显着更高（p <0.001）。有和没有瘙痒患者之间的白三烯B4，白介素-6，IgE，C3a和C5a水平没有差异。瘙痒组口服2天/天的抗过敏药盐酸氮卓斯汀3周。 11例患者中有5例瘙痒症状消失，而11例中有4例症状有所改善。与药物对瘙痒的影响无关，与瘙痒组给药前相比，白三烯B4水平显着降低（p <0.01）。白细胞介素6，C3a，C5a和嗜酸性粒细胞的数量没有显示出明显变化。总之，尽管盐酸氮卓斯汀可有效治疗血液透析患者的瘙痒，并抑制白三烯B4水平，但这些患者中白三烯B4的高活性本身似乎与瘙痒的发展无关。

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