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首页> 外文期刊>Life sciences >Antioxidant status and mineral contents in tissues of rutin and baicalin fed rats.
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Antioxidant status and mineral contents in tissues of rutin and baicalin fed rats.

机译：芦丁和黄ical素喂养的大鼠组织中的抗氧化状态和矿物质含量。

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The versatile benefit effects of flavonoids lead some nutritionists to believe that they are micronutrients. However, excess intake of flavonoids may cause side effects. In this paper, the effects produced by a higher intake of rutin and baicalin on antioxidant status as well as trace minerals such as iron, copper and zinc in rat tissues were studied. When rats were fed a rutin or baicalin containing diet (1%) for 20 days, the body weight gain was lower than that of the control group. Both rutin and baicalin caused significant a decrease of catalase activity and a moderate increase of total superoxide dismutase activity in the liver. The total antioxidant status of flavonoid fed rats was increased in the liver but decreased in the serum. In comparison to the control group, the lipid peroxidation level in the liver of the rutin fed group was significantly decreased; however, there was no statistical significance in the liver of the baicalin fed group and the brain of both flavonoids groups. The liver homogenates of both flavonoid fed rats significantly inhibited alkyl radical-induced lipid peroxidation. The iron contents in the liver of flavonoid fed rats were significantly decreased; rutin also caused zinc and copper decrease in the liver. These results indicated that high flavonoid intake can improve rat antioxidant systems in the liver; while it can also cause a trace mineral decrease and, in turn, reduce the activities of some metal-containing enzymes and may cause harmful effects on health.
机译：类黄酮的多种功效使一些营养学家认为它们是微量营养素。但是，摄入过多的类黄酮可能会引起副作用。本文研究了大量摄入芦丁和黄ical苷对大鼠组织中抗氧化剂状态以及微量矿物质如铁，铜和锌的影响。当给大鼠饲喂含芦丁或黄in素的饮食（1％）达20天时，其体重增加低于对照组。芦丁和黄ical苷均引起肝脏中过氧化氢酶活性的显着降低和总超氧化物歧化酶活性的适度提高。类黄酮喂养大鼠的总抗氧化剂状态在肝脏中升高，但在血清中降低。与对照组相比，芦丁喂养组的肝脏脂质过氧化水平显着降低。然而，黄ical苷喂养组的肝脏和两个类黄酮组的大脑中均无统计学意义。两只类黄酮喂养的大鼠的肝匀浆均显着抑制烷基自由基诱导的脂质过氧化。黄酮类食物喂养的大鼠肝脏中的铁含量明显降低;芦丁还引起肝脏中锌和铜的减少。这些结果表明，大量摄入类黄酮可以改善大鼠肝脏的抗氧化系统。同时它也可能导致微量矿物质减少，进而降低某些含金属酶的活性，并可能对健康造成有害影响。

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