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首页> 外文期刊>Cellular immunology >Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br1) in Cow Milk Allergy.
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Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br1) in Cow Milk Allergy.

机译：表征牛奶过敏中产生IL-10的调节性B细胞（Br1）的变应原特异性反应。

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摘要

CD19+CD5+ regulatory B cells regulate immune responses by producing IL-10. IL-10-producing regulatory B cell (Br1) responses by allergen stimulation were investigated in human food allergy. Six milk allergy patients and eight milk-tolerant subjects were selected according to DBPCFC. PBMCs were stimulated by casein in vitro and stained for intracellular IL-10 and apoptosis. In response to allergen stimulation, Br1 decreased from 26.2+/-18.3 to 15.5+/-8.9% (p=0.031, n=6) in the milk allergy group and increased from 15.4+/-9.0 to 23.7+/-11.2% (p=0.023, n=8) in the milk-tolerant group. Apoptotic non-IL-10-producing regulatory B cells increased from 21.8+/-9.3 to 38.0+/-16.1% (p=0.031, n=6) in the milk allergy group and unchanged from 28.8+/-13.8 to 28.0+/-15.0% (p=0.844, n=8) in the milk-tolerant group. Br1 may be involved in the immune tolerance of food allergies by producing IL-10 and simultaneously undergoing apoptosis in humans. The exact roles for Br1 in immune tolerance needs to be further investigated.
机译：CD19 + CD5 +调节性B细胞通过产生IL-10调节免疫反应。在人类食物过敏中研究了通过过敏原刺激产生IL-10的调节性B细胞（Br1）反应。根据DBPCFC选择了6名牛奶过敏患者和8名耐牛奶受试者。酪蛋白在体外刺激PBMC，并对细胞内IL-10和凋亡进行染色。响应于变应原刺激，牛奶过敏组的Br1从26.2 +/- 18.3降低到15.5 +/- 8.9％（p = 0.031，n = 6），从15.4 +/- 9.0升高到23.7 +/- 11.2％耐牛奶组中（p = 0.023，n = 8）。牛奶过敏组中不产生凋亡的非IL-10调节性B细胞从21.8 +/- 9.3增至38.0 +/- 16.1％（p = 0.031，n = 6），而从28.8 +/- 13.8不变至28.0+耐牛奶组为-1.5％（p = 0.844，n = 8）。 Br1可能通过产生IL-10并同时在人类体内发生细胞凋亡，从而参与食物过敏的免疫耐受。 Br1在免疫耐受中的确切作用有待进一步研究。

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