Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.

Dewhirst MW; Cao Y; Li CY; Moeller B

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Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.

机译：探索HIF-1在早期血管生成和放射治疗反应中的作用。

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The objective of this review is to examine the role that HIF-1 plays in the initiation of angiogenesis and in radiotherapy response. Although these two phenomena may at first seem unrelated, there are parallelisms to be drawn associated with the importance of reactive oxygen species in controlling the transcriptional activity of HIF-1, independently of its main driving force, hypoxia. Knowledge of the mechanisms underlying the control of HIF-1 leads to rationale for its inhibition in a range of clinical scenarios.

机译：这篇综述的目的是研究HIF-1在血管新生和放射治疗反应中的作用。尽管这两种现象乍一看似乎无关，但仍存在与活性氧在控制HIF-1转录活性中的重要性相关的平行性，而与HIF-1的主要驱动力低氧无关。对HIF-1控制的基本机制的了解导致了在一系列临床情况下对其抑制的理由。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2007年第3期|共7页
作者
Dewhirst MW; Cao Y; Li CY; Moeller B;
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原文格式 PDF
正文语种 eng
中图分类放射医学;肿瘤学;
关键词
Hypothalamic inhibiting factor; NOS; angiogenesis; Role; radiotherapeutic; 角色;

机译：下丘脑抑制因子;NOS;血管生成;作用;放射治疗;作用;

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1. Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy. [J] . Dewhirst MW, Cao Y, Li CY, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2007,第3期

机译：探索HIF-1在早期血管生成和放射治疗反应中的作用。
2. Critical role of hypoxia sensor - HIF-1α in VEGF gene activation. Implications for angiogenesis and tissue injury healing [J] . AhluwaliaA., TarnawskiA.S. Current medicinal chemistry . 2012,第1期

机译：低氧传感器-HIF-1α在VEGF基因激活中的关键作用。对血管生成和组织损伤愈合的影响
3. HIF-1{alpha} and HIF-2{alpha} play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. [J] . Milkiewicz M, Doyle JL, Fudalewski T, The Journal of Physiology . 2007,第Pta2期

机译：在大鼠骨骼肌中，HIF-1α和HIF-2α在拉伸诱导而不是切应力诱导的血管生成中起着核心作用。
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6. Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy [O] . Mark W. Dewhirst, Yiting Cao, Chuan Yuan Li, -1

机译：探索HIF-1在早期血管生成和对放疗反应中的作用
7. Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy [O] . Mark W. Dewhirst, Yiting Cao, Chuan Yuan Li, 2007

机译：探讨HIF-1在早期血管生成中的作用和放射治疗的反应

Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.

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