• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Significance of an exon 2 G4C14-to-A4T14 polymorphism in the p73 gene on survival in rectal cancer patients with or without preoperative radiotherapy.
【24h】

Significance of an exon 2 G4C14-to-A4T14 polymorphism in the p73 gene on survival in rectal cancer patients with or without preoperative radiotherapy.

机译：在有或没有术前放疗的直肠癌患者中，p73基因中第2外显子G4C14至A4T14多态性对生存的意义。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND PURPOSE: An exon 2 G4C14-->A4T14 polymorphism in the p73 gene was shown to be related to survival in several types of cancers, including colorectal cancer. The purpose was to investigate if this polymorphism was related to survival in rectal cancer patients with or without preoperative radiotherapy. MATERIALS AND METHODS: DNA extracted from tissue of 138 rectal cancer patients that received preoperative radiotherapy or had surgery alone was typed for the polymorphism by PCR using confronting two-pair primers. RESULTS: Among patients, 69% had GC/GC genotype, 27% had GC/AT and 4% had AT/AT. In the radiotherapy group, patients carrying the AT (GC/AT+AT/AT) allele had stronger expression of p53 (p=0.001) and survivin protein (p=0.03) than those carrying the GC/GC genotype. Further, among patients receiving preoperative radiotherapy the GC/GC genotype tended to be related to better survival (p=0.20). Patients with GC/GC genotype, along with negative p53 and weak survivin expression showed better survival than the other patients (p=0.03), even after adjusting for TNM stage and tumor differentiation (p=0.01, RR, 7.63, 95% CI, 1.50-38.74). In the non-radiotherapy group, the polymorphism was not related to survival (p=0.74). CONCLUSIONS: Results suggest that the p73 G4C14-->A4T14 polymorphism could be one factor influencing outcome of preoperative radiotherapy in rectal cancer patients.
机译：背景与目的：p73基因中的外显子2 G4C14-> A4T14多态性与多种类型的癌症（包括结直肠癌）的存活率有关。目的是研究这种多态性是否与接受或不接受术前放疗的直肠癌患者的生存有关。材料与方法：采用面对两对引物的PCR技术，对从138例接受术前放疗或仅做过手术的直肠癌患者组织中提取的DNA进行多态性分析。结果：在这些患者中，有69％具有GC / GC基因型，27％具有GC / AT，4％具有AT / AT。在放疗组中，携带AT（GC / AT + AT / AT）等位基因的患者比携带GC / GC基因型的患者具有更强的p53（p = 0.001）和survivin蛋白表达（p = 0.03）。此外，在接受术前放疗的患者中，GC / GC基因型倾向于与更好的生存率相关（p = 0.20）。即使校正了TNM分期和肿瘤分化（p = 0.01，RR，7.63、95％CI， 1.50-38.74）。在非放射治疗组中，多态性与生存率无关（p = 0.74）。结论：p73 G4C14-> A4T14基因多态性可能是影响直肠癌患者术前放疗结果的因素之一。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号