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Role for histone deacetylase 3 in maintenance of genome stability.

机译:组蛋白脱乙酰基酶3在维持基因组稳定性中的作用。

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摘要

Histone deacetylase 3 (Hdac3) is the catalytic enzyme in a transcriptional repression complex that contains the nuclear hormone co-repressors (N-CoR or SMRT). As such, Hdac3 has largely been studied in the context of gene regulation of targets of nuclear hormone receptors and other transcription factors that recruit these co-repressors. However, gene deletion studies in mice have shed new light on potential cell cycle roles of this histone deacetylase complex.
机译:组蛋白脱乙酰基酶3(Hdac3)是转录抑制复合物中的催化酶,其中含有核激素共抑制子(N-CoR或SMRT)。因此,在核激素受体和其他招募这些共阻遏物的转录因子的靶基因调控的背景下,对Hdac3进行了大量研究。然而,在小鼠中进行的基因删除研究为这种组蛋白脱乙酰基酶复合物的潜在细胞周期作用提供了新的思路。

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